Beyond the RNA World: Empirical Evidence for DNA-RNA Co-evolution in Early Life(Estimated Calculating Simulation)
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2025
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| _version_ | 1866901361959895040 |
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| author | Reza Hashemi |
| author_facet | Reza Hashemi |
| contents | <p>The RNA World Hypothesis has dominated origins-of-life research for decades, but faces significant empirical challenges. Here we demonstrate through kinetic modeling with wet-lab validated rate constants that DNA, not RNA, dominates nonenzymatic polymerization under common prebiotic conditions. DNA/RNA ratios average 7.3:1 with DNA comprising 87% of oligomers. We address key objections to DNA's early role: (1) deoxynucleotide synthesis occurs efficiently under montmorillonite redox conditions, (2) DNA's geological instability explains its absence from ancient records, and (3) modern ribozymes represent evolutionary optimizations, not prebiotic realities. We propose the Matter World Hypothesis: (RNA, DNA, peptides, lipids, polyphosphates, and mineral catalysts), emerged together, each contributing unique chemical capabilities from life's inception.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18072917 |
| institution | Zenodo |
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| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Beyond the RNA World: Empirical Evidence for DNA-RNA Co-evolution in Early Life(Estimated Calculating Simulation) Reza Hashemi RNA World Hypothesis,Matter World Hypothesis,nonenzymatic polymerization,deoxynucleotide synthesis,montmorillonite, redox conditions, <p>The RNA World Hypothesis has dominated origins-of-life research for decades, but faces significant empirical challenges. Here we demonstrate through kinetic modeling with wet-lab validated rate constants that DNA, not RNA, dominates nonenzymatic polymerization under common prebiotic conditions. DNA/RNA ratios average 7.3:1 with DNA comprising 87% of oligomers. We address key objections to DNA's early role: (1) deoxynucleotide synthesis occurs efficiently under montmorillonite redox conditions, (2) DNA's geological instability explains its absence from ancient records, and (3) modern ribozymes represent evolutionary optimizations, not prebiotic realities. We propose the Matter World Hypothesis: (RNA, DNA, peptides, lipids, polyphosphates, and mineral catalysts), emerged together, each contributing unique chemical capabilities from life's inception.</p> |
| title | Beyond the RNA World: Empirical Evidence for DNA-RNA Co-evolution in Early Life(Estimated Calculating Simulation) |
| topic | RNA World Hypothesis,Matter World Hypothesis,nonenzymatic polymerization,deoxynucleotide synthesis,montmorillonite, redox conditions, |
| url | https://doi.org/10.5281/zenodo.18072917 |