A Comparative Study to Assess Maternal Serum Prolactin Levels in Women with Pre-eclampsia and Normal Pregnancy
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| Natura: | Recurso digital |
| Lingua: | inglese |
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Zenodo
2025
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| _version_ | 1866901100242665472 |
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| author | International Journal of Medical Science and Innovative Research (IJMSIR) |
| author_facet | International Journal of Medical Science and Innovative Research (IJMSIR) |
| contents | <p><strong><span>Abstract</span></strong></p> <p><strong><span lang="EN-IN">Introduction</span></strong><span lang="EN-IN">: Pre-eclampsia is a hypertensive disorder of pregnancy that contributes significantly to maternal and perinatal morbidity and mortality. Its exact etiology remains unclear; though hormonal changes are thought to play a role. This study aimed to compare maternal serum prolactin levels in women with pre-eclampsia and normotensive pregnancies and evaluate the association between prolactin levels and severity of pre-eclampsia. </span></p> <p><strong><span lang="EN-IN">Methods</span></strong><span lang="EN-IN">: This prospective cross-sectional study was conducted at the Department of Obstetrics and Gynaecology, Sawai Man Singh Medical College, Jaipur. A total of 100 pregnant women beyond 20 weeks of gestation were included: 50 with pre-eclampsia and 50 normotensive controls, all with singleton pregnancies. Serum prolactin levels were measured using chemiluminescence immunoassay. Data were analyzed using SPSS software. A p-value < 0.05 was considered statistically significant.</span></p> <p><strong><span lang="EN-IN">Results</span></strong><span lang="EN-IN">: The mean serum prolactin level in the pre-eclamptic group was significantly higher (465.1 ± 103.44 μIU/ml) compared to the normotensive group (185.36 ± 80.34 μIU/ml, p < 0.0001). Within the pre-eclamptic group, women with severe pre-eclampsia had higher prolactin levels (476.13 ± 102.98 μIU/ml) than those with mild pre-eclampsia (433.69 ± 102.13 μIU/ml), though the difference was not statistically significant (p = 0.3). Prolactin levels were strongly positively correlated with systolic (r = 0.779) and diastolic (r = 0.698) blood pressure (p < 0.001 for both).</span></p> <p><strong><span lang="EN-IN">Conclusion</span></strong><span lang="EN-IN">: The findings suggest that elevated maternal serum prolactin is significantly associated with pre-eclampsia and correlates with blood pressure levels. Although levels were higher in severe cases, the difference was not significant. Prolactin may have potential as a biomarker for pre-eclampsia diagnosis and severity assessment.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18083314 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | A Comparative Study to Assess Maternal Serum Prolactin Levels in Women with Pre-eclampsia and Normal Pregnancy International Journal of Medical Science and Innovative Research (IJMSIR) Pre-eclampsia, Serum prolactin, Normotensive pregnancy, Hypertension, Biomarker, Maternal outcome, Foetal outcome <p><strong><span>Abstract</span></strong></p> <p><strong><span lang="EN-IN">Introduction</span></strong><span lang="EN-IN">: Pre-eclampsia is a hypertensive disorder of pregnancy that contributes significantly to maternal and perinatal morbidity and mortality. Its exact etiology remains unclear; though hormonal changes are thought to play a role. This study aimed to compare maternal serum prolactin levels in women with pre-eclampsia and normotensive pregnancies and evaluate the association between prolactin levels and severity of pre-eclampsia. </span></p> <p><strong><span lang="EN-IN">Methods</span></strong><span lang="EN-IN">: This prospective cross-sectional study was conducted at the Department of Obstetrics and Gynaecology, Sawai Man Singh Medical College, Jaipur. A total of 100 pregnant women beyond 20 weeks of gestation were included: 50 with pre-eclampsia and 50 normotensive controls, all with singleton pregnancies. Serum prolactin levels were measured using chemiluminescence immunoassay. Data were analyzed using SPSS software. A p-value < 0.05 was considered statistically significant.</span></p> <p><strong><span lang="EN-IN">Results</span></strong><span lang="EN-IN">: The mean serum prolactin level in the pre-eclamptic group was significantly higher (465.1 ± 103.44 μIU/ml) compared to the normotensive group (185.36 ± 80.34 μIU/ml, p < 0.0001). Within the pre-eclamptic group, women with severe pre-eclampsia had higher prolactin levels (476.13 ± 102.98 μIU/ml) than those with mild pre-eclampsia (433.69 ± 102.13 μIU/ml), though the difference was not statistically significant (p = 0.3). Prolactin levels were strongly positively correlated with systolic (r = 0.779) and diastolic (r = 0.698) blood pressure (p < 0.001 for both).</span></p> <p><strong><span lang="EN-IN">Conclusion</span></strong><span lang="EN-IN">: The findings suggest that elevated maternal serum prolactin is significantly associated with pre-eclampsia and correlates with blood pressure levels. Although levels were higher in severe cases, the difference was not significant. Prolactin may have potential as a biomarker for pre-eclampsia diagnosis and severity assessment.</span></p> |
| title | A Comparative Study to Assess Maternal Serum Prolactin Levels in Women with Pre-eclampsia and Normal Pregnancy |
| topic | Pre-eclampsia, Serum prolactin, Normotensive pregnancy, Hypertension, Biomarker, Maternal outcome, Foetal outcome |
| url | https://doi.org/10.5281/zenodo.18083314 |