A Prospective Observational Comparative Study of Liquid-Based Cytology and Pap Smears
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| Natura: | Recurso digital |
| Lingua: | inglese |
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2025
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| _version_ | 1866901795108814848 |
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| author | International Journal of Medical Science and Innovative Research (IJMSIR) |
| author_facet | International Journal of Medical Science and Innovative Research (IJMSIR) |
| contents | <p><strong><span>Abstract</span></strong></p> <p><strong><span>Introduction: </span></strong><span>Liquid-Based Cytology and Pap Smears: Which is the Better Choice?"</span></p> <p><strong><span>Objectives: </span></strong><span>This study aimed to compare the cytomorphological differences between Liquid-Based Cytology (LBC) and Conventional Pap Smear (CPS). Additionally, it sought to evaluate the relative advantages and limitations of both techniques.</span></p> <p><strong><span>Materials: </span></strong><span>A total of 300 cases were analyzed. Conventional Pap Smear samples were collected using a cytobrush, while the cervical brush head was suspended in an LBC vial and processed using the Sure Path system.</span></p> <p><strong><span>Results: </span></strong><span>The study involved participants aged <span>31 to 80<strong> </strong></span>years, with a mean age of 54.1 years. Among the 300 cases, 280 satisfactory smears were obtained using CPS, compared to 292 using LBC. Inflammatory smears were detected in 204 cases (68%) with CPS and 219 cases (73 %) with LBC. CPS identified 9 cases of Low-Grade Squamous Intraepithelial Lesion (LSIL) and 3 cases of High-Grade Squamous Intraepithelial Lesion (HSIL), while LBC identified 9 cases of LSIL, 6 cases of HSIL, and 2 cases of squamous cell carcinoma. Histopathological correlation was conducted in 20 cases, where LBC demonstrated 100% sensitivity and specificity.</span></p> <p><strong><span>Conclusion: </span></strong><span>LBC outperformed CPS in terms of adequacy, background clarity, infection detection, and sensitivity and specificity for identifying LSIL and HSIL. These findings suggest that LBC is a superior method for cervical cytology.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18085081 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | A Prospective Observational Comparative Study of Liquid-Based Cytology and Pap Smears International Journal of Medical Science and Innovative Research (IJMSIR) Cervical Cancer, Cervical Brush Conventional Pap Smear Sensitivity <p><strong><span>Abstract</span></strong></p> <p><strong><span>Introduction: </span></strong><span>Liquid-Based Cytology and Pap Smears: Which is the Better Choice?"</span></p> <p><strong><span>Objectives: </span></strong><span>This study aimed to compare the cytomorphological differences between Liquid-Based Cytology (LBC) and Conventional Pap Smear (CPS). Additionally, it sought to evaluate the relative advantages and limitations of both techniques.</span></p> <p><strong><span>Materials: </span></strong><span>A total of 300 cases were analyzed. Conventional Pap Smear samples were collected using a cytobrush, while the cervical brush head was suspended in an LBC vial and processed using the Sure Path system.</span></p> <p><strong><span>Results: </span></strong><span>The study involved participants aged <span>31 to 80<strong> </strong></span>years, with a mean age of 54.1 years. Among the 300 cases, 280 satisfactory smears were obtained using CPS, compared to 292 using LBC. Inflammatory smears were detected in 204 cases (68%) with CPS and 219 cases (73 %) with LBC. CPS identified 9 cases of Low-Grade Squamous Intraepithelial Lesion (LSIL) and 3 cases of High-Grade Squamous Intraepithelial Lesion (HSIL), while LBC identified 9 cases of LSIL, 6 cases of HSIL, and 2 cases of squamous cell carcinoma. Histopathological correlation was conducted in 20 cases, where LBC demonstrated 100% sensitivity and specificity.</span></p> <p><strong><span>Conclusion: </span></strong><span>LBC outperformed CPS in terms of adequacy, background clarity, infection detection, and sensitivity and specificity for identifying LSIL and HSIL. These findings suggest that LBC is a superior method for cervical cytology.</span></p> |
| title | A Prospective Observational Comparative Study of Liquid-Based Cytology and Pap Smears |
| topic | Cervical Cancer, Cervical Brush Conventional Pap Smear Sensitivity |
| url | https://doi.org/10.5281/zenodo.18085081 |