ANTIINFLAMMATORY AND ANTIOXIDANT ACTIVITY OF POMEGRANATE PEEL EXTRACT
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| Formato: | Recurso digital |
| Lenguaje: | inglés |
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Zenodo
2026
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| _version_ | 1866901660659351552 |
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| author | B. L. Nanda1*, B. S. Vishwanath2 |
| author_facet | B. L. Nanda1*, B. S. Vishwanath2 |
| contents | <p><span>Secretory PLA<sub>2 </sub>(sPLA<sub>2</sub>-IIA) is implicated in inflammatory responses because a high level of this enzyme has been found in inflammatory fluids and cells. PLA<sub>2</sub> enzyme catalyses the breakdown of membrane phospholipid to arachidonic acid and lysophospholipid. Arachidonic acid is in turn converted to proinflammatory mediators and ROS. A single molecule having both antioxidant and PLA<sub>2</sub> inhibition is of great therapeutic importance in designing anti-inflammatory molecules. Pomegranate peel extracted with different solvents with increasing polarity were screened for phenolics, antioxidant activity and sPLA<sub>2</sub> inhibition. The acetone extract exhibited high antioxidant activity and sPLA<sub>2</sub> inhibition. The concentration of phenolics directly correlated with antioxidant activity and PLA<sub>2</sub> inhibition.<span> P.granatum</span> peel acetone extract also showed dose dependent inhibition of sPLA<sub>2</sub> enzyme both by invitro and invivo method. The <span>P.granatum</span> peel acetone extract was further subjected to TLC for separation of components in extract. The extract showed 7-8 bands. Each band was subjected to PLA<sub>2</sub> inhibition and antioxidant activity. PPCII was found to have high PLA<sub>2</sub> inhibition and antioxidant activity. The extract may contain compounds (Phenolics, anthocyanins, flavonoids, tannins, alkaloids) which are both antioxidant and anti-inflammatory in nature and they can be used for clinical development as a new class of anti-inflammatory agents with antioxidant activity.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18094415 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | ANTIINFLAMMATORY AND ANTIOXIDANT ACTIVITY OF POMEGRANATE PEEL EXTRACT B. L. Nanda1*, B. S. Vishwanath2 <p><span>Secretory PLA<sub>2 </sub>(sPLA<sub>2</sub>-IIA) is implicated in inflammatory responses because a high level of this enzyme has been found in inflammatory fluids and cells. PLA<sub>2</sub> enzyme catalyses the breakdown of membrane phospholipid to arachidonic acid and lysophospholipid. Arachidonic acid is in turn converted to proinflammatory mediators and ROS. A single molecule having both antioxidant and PLA<sub>2</sub> inhibition is of great therapeutic importance in designing anti-inflammatory molecules. Pomegranate peel extracted with different solvents with increasing polarity were screened for phenolics, antioxidant activity and sPLA<sub>2</sub> inhibition. The acetone extract exhibited high antioxidant activity and sPLA<sub>2</sub> inhibition. The concentration of phenolics directly correlated with antioxidant activity and PLA<sub>2</sub> inhibition.<span> P.granatum</span> peel acetone extract also showed dose dependent inhibition of sPLA<sub>2</sub> enzyme both by invitro and invivo method. The <span>P.granatum</span> peel acetone extract was further subjected to TLC for separation of components in extract. The extract showed 7-8 bands. Each band was subjected to PLA<sub>2</sub> inhibition and antioxidant activity. PPCII was found to have high PLA<sub>2</sub> inhibition and antioxidant activity. The extract may contain compounds (Phenolics, anthocyanins, flavonoids, tannins, alkaloids) which are both antioxidant and anti-inflammatory in nature and they can be used for clinical development as a new class of anti-inflammatory agents with antioxidant activity.</span></p> |
| title | ANTIINFLAMMATORY AND ANTIOXIDANT ACTIVITY OF POMEGRANATE PEEL EXTRACT |
| url | https://doi.org/10.5281/zenodo.18094415 |