Hepatoprotective activity of ethanolic peel extract of Saccharum officinarum L. against thioacetamide - induced liver injury in albino rats
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| Formato: | Recurso digital |
| Lenguaje: | inglés |
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2026
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| _version_ | 1866901545857056768 |
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| author | Duru, Amarachi Chandria Okwuosa, Chukwugozie Nwachukwu Francis, Blessing |
| author_facet | Duru, Amarachi Chandria Okwuosa, Chukwugozie Nwachukwu Francis, Blessing |
| contents | <p><span>The liver plays an essential role in metabolism and detoxification, making it prone to damage by chemical agents. This study evaluated the hepatoprotective activity of ethanolic peel extract of <em>Saccharum officinarum</em> (SOPE) against thioacetamide (TAA) - induced liver injury in albino Wistar rats. Twenty-five rats were divided into five groups of five each. Two groups received 125 mg/kg and 250 mg/kg of SOPE, respectively, one received zinc lactate (200 mg/kg), one served as the normal control, and one as the TAA-only group. Treatments were administered orally for six days, followed by TAA (200 mg/kg, i.p.) on day seven. Biochemical markers (ALT, AST, ALP, total bilirubin, and albumin) and histopathological changes were assessed. SOPE significantly reduced (p < 0.001) ALT, AST, ALP, and total bilirubin levels, while increasing albumin in a dose-dependent manner. Histological results confirmed hepatoprotection, showing preserved hepatic structures in SOPE - treated rats compared with the TAA<span> </span>-only group. These findings suggest that <em>Saccharum officinarum</em> peel extract possesses potent hepatoprotective activity likely due to its antioxidant phytochemicals.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18113838 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Hepatoprotective activity of ethanolic peel extract of Saccharum officinarum L. against thioacetamide - induced liver injury in albino rats Duru, Amarachi Chandria Okwuosa, Chukwugozie Nwachukwu Francis, Blessing Saccharum officinarum, hepatoprotection, thioacetamide, liver enzymes, oxidative stress, Wistar rats <p><span>The liver plays an essential role in metabolism and detoxification, making it prone to damage by chemical agents. This study evaluated the hepatoprotective activity of ethanolic peel extract of <em>Saccharum officinarum</em> (SOPE) against thioacetamide (TAA) - induced liver injury in albino Wistar rats. Twenty-five rats were divided into five groups of five each. Two groups received 125 mg/kg and 250 mg/kg of SOPE, respectively, one received zinc lactate (200 mg/kg), one served as the normal control, and one as the TAA-only group. Treatments were administered orally for six days, followed by TAA (200 mg/kg, i.p.) on day seven. Biochemical markers (ALT, AST, ALP, total bilirubin, and albumin) and histopathological changes were assessed. SOPE significantly reduced (p < 0.001) ALT, AST, ALP, and total bilirubin levels, while increasing albumin in a dose-dependent manner. Histological results confirmed hepatoprotection, showing preserved hepatic structures in SOPE - treated rats compared with the TAA<span> </span>-only group. These findings suggest that <em>Saccharum officinarum</em> peel extract possesses potent hepatoprotective activity likely due to its antioxidant phytochemicals.</span></p> |
| title | Hepatoprotective activity of ethanolic peel extract of Saccharum officinarum L. against thioacetamide - induced liver injury in albino rats |
| topic | Saccharum officinarum, hepatoprotection, thioacetamide, liver enzymes, oxidative stress, Wistar rats |
| url | https://doi.org/10.5281/zenodo.18113838 |