Antibiotic Resistant Patterns of Enterococcus Species Isolated from Clinical Samples in a Nigerian Private Tertiary Medical Centre
Fuente:
Zenodo
Enregistré dans:
| Auteurs principaux: | , |
|---|---|
| Format: | Recurso digital |
| Publié: |
Zenodo
2025
|
| Sujets: | |
| Accès en ligne: | |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|
| _version_ | 1866901373348478976 |
|---|---|
| author | Abdullahi, N Oranekwulu, MU |
| author_facet | Abdullahi, N Oranekwulu, MU |
| contents | <div><span>ABSTRACT </span></div> <div><span>Enterococci </span><span>cause serious nosocomial infections which are characteristically associated with high mortality rates and </span><span>treatment challenges because the bacteria are not only innately resistant to some antibiotics but also possess the ability </span><span>to develop acquired resistance to virtually all clinically beneficial antimicrobial agents. This study was carried out to </span><span>determine the antibiotics resistant patterns among isolates of </span><span>Enterococci </span><span>from clinical samples so as to provide </span><span>knowledge that will inform the appropriate antimicrobial choice for its infections in this setting. It was a descriptive, </span><span>cross-sectional retrospective study conducted over a period of 18 months (February 2024 – August 2025) at the medical </span><span>microbiology laboratory of Nisa Premiers Hospital. Laboratory records of all </span><span>Enterococci </span><span>isolated from various clinical </span><span>specimens submitted for culture as well as their susceptibility rates to variously tested antibiotics were extracted, </span><span>reviewed and analyzed., Specimen culture and antimicrobial sensitivity testing of isolates were performed following </span><span>standard microbiological methods. Forty-one (41) isolates of Enterococci were recovered from the various clinical </span><span>samples processed. Thirty-five (85.4%) of all the isolates were </span><span>Enterococcus </span><span>faecalis, while 6 (14.6%) were </span><span>Enterococcus faecium. </span><span>Enterococc</span><span>i were most frequently isolated from urine 36 (87.8%). The prevalence rate of </span><span>vancomycin-resistant </span><span>Enterococcus</span><span>(VRE) was 27.5%. </span><span>Enterococc</span><span>us was highly resistant to ciprofloxacin (85.7%) and </span><span>doxycycline (57.9%), relatively highly resistant to linezolid (25%), but displayed the least resistance to nitrofurantoin </span><span>(18.7%). In conclusion, the most frequent enterococcal infection was UTI, and </span><span>Enterococcus </span><span>faecalis was the most </span><span>frequent species causing infections in this study. There were relatively high prevalence rates of both VRE and </span><span>Linezolid-resistant </span><span>Enterococcus</span><span>. There is, therefore, a need for strengthening of antimicrobial stewardship program, </span></div> <div><span>implementation of infection control measures and routine surveillance in order to reduce the emergence of resistant </span><span>strain and control its spread.</span></div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18125435 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Antibiotic Resistant Patterns of Enterococcus Species Isolated from Clinical Samples in a Nigerian Private Tertiary Medical Centre Abdullahi, N Oranekwulu, MU Clinical Samples Enterococci Resistant Patterns <div><span>ABSTRACT </span></div> <div><span>Enterococci </span><span>cause serious nosocomial infections which are characteristically associated with high mortality rates and </span><span>treatment challenges because the bacteria are not only innately resistant to some antibiotics but also possess the ability </span><span>to develop acquired resistance to virtually all clinically beneficial antimicrobial agents. This study was carried out to </span><span>determine the antibiotics resistant patterns among isolates of </span><span>Enterococci </span><span>from clinical samples so as to provide </span><span>knowledge that will inform the appropriate antimicrobial choice for its infections in this setting. It was a descriptive, </span><span>cross-sectional retrospective study conducted over a period of 18 months (February 2024 – August 2025) at the medical </span><span>microbiology laboratory of Nisa Premiers Hospital. Laboratory records of all </span><span>Enterococci </span><span>isolated from various clinical </span><span>specimens submitted for culture as well as their susceptibility rates to variously tested antibiotics were extracted, </span><span>reviewed and analyzed., Specimen culture and antimicrobial sensitivity testing of isolates were performed following </span><span>standard microbiological methods. Forty-one (41) isolates of Enterococci were recovered from the various clinical </span><span>samples processed. Thirty-five (85.4%) of all the isolates were </span><span>Enterococcus </span><span>faecalis, while 6 (14.6%) were </span><span>Enterococcus faecium. </span><span>Enterococc</span><span>i were most frequently isolated from urine 36 (87.8%). The prevalence rate of </span><span>vancomycin-resistant </span><span>Enterococcus</span><span>(VRE) was 27.5%. </span><span>Enterococc</span><span>us was highly resistant to ciprofloxacin (85.7%) and </span><span>doxycycline (57.9%), relatively highly resistant to linezolid (25%), but displayed the least resistance to nitrofurantoin </span><span>(18.7%). In conclusion, the most frequent enterococcal infection was UTI, and </span><span>Enterococcus </span><span>faecalis was the most </span><span>frequent species causing infections in this study. There were relatively high prevalence rates of both VRE and </span><span>Linezolid-resistant </span><span>Enterococcus</span><span>. There is, therefore, a need for strengthening of antimicrobial stewardship program, </span></div> <div><span>implementation of infection control measures and routine surveillance in order to reduce the emergence of resistant </span><span>strain and control its spread.</span></div> |
| title | Antibiotic Resistant Patterns of Enterococcus Species Isolated from Clinical Samples in a Nigerian Private Tertiary Medical Centre |
| topic | Clinical Samples Enterococci Resistant Patterns |
| url | https://doi.org/10.5281/zenodo.18125435 |