Chemical Safety and Toxicology: A Comprehensive Review of Current Protocols and Principles
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| Formato: | Recurso digital |
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2025
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| _version_ | 1866901352498593792 |
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| author | Bordikar, Chetan P. |
| author_facet | Bordikar, Chetan P. |
| contents | <p><strong><em><span>Abstract</span></em></strong></p> <p><em><span>This comprehensive review examines the latest advances in chemical safety protocols and toxicological principles, synthesizing current research findings from 2020-2025. The review encompasses emerging non-animal testing methodologies (NAMs), and regulatory compliance requirements. Key findings reveal a paradigm shift toward integrated tiered assessment approaches that combine in silico, in vitro, and targeted in vivo methods, alongside structured control banding systems for workplace exposure management. The analysis demonstrates that contemporary chemical safety practice emphasizes source-control engineering, administrative procedures, and competency-based training, while toxicological assessment increasingly adopts adverse outcome pathways (AOPs) and read-across strategies to reduce animal testing. This review provides researchers, safety professionals, and regulatory bodies with an evidence-based synthesis of current best practices and emerging trends in chemical safety and toxicology.</span></em></p> <p> </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18144425 |
| institution | Zenodo |
| language | |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Chemical Safety and Toxicology: A Comprehensive Review of Current Protocols and Principles Bordikar, Chetan P. Keywords: Chemical safety, toxicology, NAMs <p><strong><em><span>Abstract</span></em></strong></p> <p><em><span>This comprehensive review examines the latest advances in chemical safety protocols and toxicological principles, synthesizing current research findings from 2020-2025. The review encompasses emerging non-animal testing methodologies (NAMs), and regulatory compliance requirements. Key findings reveal a paradigm shift toward integrated tiered assessment approaches that combine in silico, in vitro, and targeted in vivo methods, alongside structured control banding systems for workplace exposure management. The analysis demonstrates that contemporary chemical safety practice emphasizes source-control engineering, administrative procedures, and competency-based training, while toxicological assessment increasingly adopts adverse outcome pathways (AOPs) and read-across strategies to reduce animal testing. This review provides researchers, safety professionals, and regulatory bodies with an evidence-based synthesis of current best practices and emerging trends in chemical safety and toxicology.</span></em></p> <p> </p> |
| title | Chemical Safety and Toxicology: A Comprehensive Review of Current Protocols and Principles |
| topic | Keywords: Chemical safety, toxicology, NAMs |
| url | https://doi.org/10.5281/zenodo.18144425 |