The Evaluation of the Solvent Fractions of the Fruits, Leaves, and the Stem Bark of Sarcocephalus Latifolius (sm.) E. A. Bruce for Cytotoxicity and Antioxidant Activities
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2025
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| _version_ | 1866901921125629952 |
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| author | Imah-Harry, J. U Omotosho, S. O Odine, G. O |
| author_facet | Imah-Harry, J. U Omotosho, S. O Odine, G. O |
| contents | <p><span lang="EN">The attention in the use of medicinal plants in the treatment of various ailments in humans, cancer inclusive has gained significant consideration. Despite the innovations in technology, and the advent of foremost therapies, there is a growing inclination towards herbal medicine.<span> </span><em>Sarcocephalus latifolius</em> (SL) is used in folkloric medicine for the treatment of cancer but there are no scientific data to support this claim. The study evaluated the antioxidant and the cytotoxicity activities of the fruits, leaves and the stem bark of SL. These plant parts were harvested, washed, air-dried, pulverised and soaked in 100% methanol to obtain the crude methanol extracts (CMESL, MCESLL and CMESBSL). These were partitioned successively between n-hexane chloroform, ethyl acetate and methanol to obtain their respective fractions, N-hexane (HFSL,</span><span lang="EN"> </span><span lang="EN">HFSLL and HFSBSL), chloroform (CFSL, CFSLL, and CFSBSL), ethyl acetate (EFSL, EFSLL, and EFSBSL), and the methanol (MFSL, MFSLL and MFSBSL). These extracts and fractions were subjected to <em>in vitro</em> antioxidant assays (DPPH, TAC, TPC and FRAP) and an <em>in vivo</em> cytotoxicity test using the brine shrimp lethality test (BSLT), to determine their LC<sub>50</sub>. The results reveal that CFSL, CFSLL and CFSBSL is the most cytotoxic when compared to the other fractions, and for the antioxidant assays, the ethyl acetate fractions of the leaves and stem bark, EFSLL, and EFSBSL and the chloroform fraction, CFSL of the fruits, had the peak activity. </span></p> <p><em><span lang="EN">Sarcocephalus latifolius</span></em><span lang="EN"> plant demonstrates the potential as a good source of antioxidants and might have bioactive agents responsible for the anticancer effects. </span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18168364 |
| institution | Zenodo |
| language | eng |
| publishDate | 2025 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | The Evaluation of the Solvent Fractions of the Fruits, Leaves, and the Stem Bark of Sarcocephalus Latifolius (sm.) E. A. Bruce for Cytotoxicity and Antioxidant Activities Imah-Harry, J. U Omotosho, S. O Odine, G. O medicinal plants Sarcocephalus latifolius antioxidant cytotoxicity bioactive agents <p><span lang="EN">The attention in the use of medicinal plants in the treatment of various ailments in humans, cancer inclusive has gained significant consideration. Despite the innovations in technology, and the advent of foremost therapies, there is a growing inclination towards herbal medicine.<span> </span><em>Sarcocephalus latifolius</em> (SL) is used in folkloric medicine for the treatment of cancer but there are no scientific data to support this claim. The study evaluated the antioxidant and the cytotoxicity activities of the fruits, leaves and the stem bark of SL. These plant parts were harvested, washed, air-dried, pulverised and soaked in 100% methanol to obtain the crude methanol extracts (CMESL, MCESLL and CMESBSL). These were partitioned successively between n-hexane chloroform, ethyl acetate and methanol to obtain their respective fractions, N-hexane (HFSL,</span><span lang="EN"> </span><span lang="EN">HFSLL and HFSBSL), chloroform (CFSL, CFSLL, and CFSBSL), ethyl acetate (EFSL, EFSLL, and EFSBSL), and the methanol (MFSL, MFSLL and MFSBSL). These extracts and fractions were subjected to <em>in vitro</em> antioxidant assays (DPPH, TAC, TPC and FRAP) and an <em>in vivo</em> cytotoxicity test using the brine shrimp lethality test (BSLT), to determine their LC<sub>50</sub>. The results reveal that CFSL, CFSLL and CFSBSL is the most cytotoxic when compared to the other fractions, and for the antioxidant assays, the ethyl acetate fractions of the leaves and stem bark, EFSLL, and EFSBSL and the chloroform fraction, CFSL of the fruits, had the peak activity. </span></p> <p><em><span lang="EN">Sarcocephalus latifolius</span></em><span lang="EN"> plant demonstrates the potential as a good source of antioxidants and might have bioactive agents responsible for the anticancer effects. </span></p> |
| title | The Evaluation of the Solvent Fractions of the Fruits, Leaves, and the Stem Bark of Sarcocephalus Latifolius (sm.) E. A. Bruce for Cytotoxicity and Antioxidant Activities |
| topic | medicinal plants Sarcocephalus latifolius antioxidant cytotoxicity bioactive agents |
| url | https://doi.org/10.5281/zenodo.18168364 |