Glyconnection: AI-assisted Glycosidic Linkage Optimization Platform

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Autore principale: Shahat Belal, Ahmed
Natura: Recurso digital
Pubblicazione: Zenodo 2026
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_version_ 1866902003664289792
author Shahat Belal, Ahmed
author_facet Shahat Belal, Ahmed
contents <p>This release represents the first Zenodo-linked public version of Glyconnection.</p> <p>Glyconnection is an AI-guided cheminformatics platform for systematic analysis of glycosidic linkage variants between aglycone and sugar moieties. The tool automatically generates multiple glycosidic linkage types (O-, N-, S-, and C-glycosides), computes molecular descriptors using RDKit, evaluates comparative drug-likeness and ADMET-related properties, and ranks the variants based on a composite scoring strategy.</p> <p>Key features in this release:</p> <ul> <li>Automated generation of O/N/S/C glycosidic variants</li> <li>Descriptor calculation using RDKit (physicochemical and drug-relevant properties)</li> <li>Scoring and ranking of linkage variants</li> <li>Scientific explanation of the selected optimal linkage</li> <li>Persistent storage of results via Supabase integration</li> <li>Web-based interactive interface for live compound analysis</li> </ul> <p>This release is intended for academic research, early-stage drug design exploration, and educational use in glycoscience and cheminformatics.</p>
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publishDate 2026
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spellingShingle Glyconnection: AI-assisted Glycosidic Linkage Optimization Platform
Shahat Belal, Ahmed
glycosides
drug design
cheminformatics
rdkit
ai
admet
<p>This release represents the first Zenodo-linked public version of Glyconnection.</p> <p>Glyconnection is an AI-guided cheminformatics platform for systematic analysis of glycosidic linkage variants between aglycone and sugar moieties. The tool automatically generates multiple glycosidic linkage types (O-, N-, S-, and C-glycosides), computes molecular descriptors using RDKit, evaluates comparative drug-likeness and ADMET-related properties, and ranks the variants based on a composite scoring strategy.</p> <p>Key features in this release:</p> <ul> <li>Automated generation of O/N/S/C glycosidic variants</li> <li>Descriptor calculation using RDKit (physicochemical and drug-relevant properties)</li> <li>Scoring and ranking of linkage variants</li> <li>Scientific explanation of the selected optimal linkage</li> <li>Persistent storage of results via Supabase integration</li> <li>Web-based interactive interface for live compound analysis</li> </ul> <p>This release is intended for academic research, early-stage drug design exploration, and educational use in glycoscience and cheminformatics.</p>
title Glyconnection: AI-assisted Glycosidic Linkage Optimization Platform
topic glycosides
drug design
cheminformatics
rdkit
ai
admet
url https://doi.org/10.5281/zenodo.18236882