IM-JW/ticagrelor-popPK: v1.0.0 - Initial release
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2026
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| author | IM-JW |
| author_facet | IM-JW |
| contents | <h1>Ticagrelor Population Pharmacokinetic Analysis</h1> <p>Code repository for the manuscript: <strong>"Population pharmacokinetics of ticagrelor in patients with acute coronary syndrome: A pooled pharmacokinetic analysis"</strong></p> <h2>Overview</h2> <p>This repository contains R and mrgsolve code for virtual cohort generation, population PK simulation of ticagrelor and AR-C124910XX, and dose optimization analysis.</p> <h2>File Description</h2> <h3>Virtual Cohort Generation (R scripts)</h3> <ul> <li><code>2016 csv generation.R</code> - Generate virtual patients from Li et al. 2016 (Study 1)</li> <li><code>2017_60 csv generation.R</code> - Generate virtual patients from Röshammar et al. 2017 (60mg)</li> <li><code>2017_90 csv generation.R</code> - Generate virtual patients from Röshammar et al. 2017 (90mg)</li> </ul> <h3>mrgsolve Model Files (.cpp)</h3> <ul> <li><code>2016_mod_0_cov add.cpp</code> - ADME structure for Study 1</li> <li><code>2017_60_mod_0.cpp</code> - ADME structure for Study 2 (60mg)</li> <li><code>2017_90_mod_0.cpp</code> - ADME structure for Study 2 (90mg)</li> </ul> <h3>Simulation</h3> <ul> <li><code>[1] sim_csv_file.R</code> - Simulation execution script</li> <li><code>[2] sim_control_making.R</code> - Generate simulation control parameters</li> </ul> <h3>Data</h3> <ul> <li><code>final_data_set_base.csv</code> - Pooled virtual patient dataset (n=1,000)</li> </ul> <h2>Requirements</h2> <ul> <li>R (≥ 4.3.1)</li> <li>mrgsolve</li> <li>tidyverse</li> </ul> <h2>References</h2> <ul> <li>Li J, et al. Population pharmacokinetics of ticagrelor in patients with acute coronary syndromes. Int J Clin Pharmacol Ther. 2016;54:666-674.</li> <li>Röshammar D, et al. Population pharmacokinetics of ticagrelor and AR-C124910XX in patients with prior myocardial infarction. Int J Clin Pharmacol Ther. 2017;55:416-424.</li> </ul> <h2>License</h2> <p>MIT License</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18251968 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | IM-JW/ticagrelor-popPK: v1.0.0 - Initial release IM-JW <h1>Ticagrelor Population Pharmacokinetic Analysis</h1> <p>Code repository for the manuscript: <strong>"Population pharmacokinetics of ticagrelor in patients with acute coronary syndrome: A pooled pharmacokinetic analysis"</strong></p> <h2>Overview</h2> <p>This repository contains R and mrgsolve code for virtual cohort generation, population PK simulation of ticagrelor and AR-C124910XX, and dose optimization analysis.</p> <h2>File Description</h2> <h3>Virtual Cohort Generation (R scripts)</h3> <ul> <li><code>2016 csv generation.R</code> - Generate virtual patients from Li et al. 2016 (Study 1)</li> <li><code>2017_60 csv generation.R</code> - Generate virtual patients from Röshammar et al. 2017 (60mg)</li> <li><code>2017_90 csv generation.R</code> - Generate virtual patients from Röshammar et al. 2017 (90mg)</li> </ul> <h3>mrgsolve Model Files (.cpp)</h3> <ul> <li><code>2016_mod_0_cov add.cpp</code> - ADME structure for Study 1</li> <li><code>2017_60_mod_0.cpp</code> - ADME structure for Study 2 (60mg)</li> <li><code>2017_90_mod_0.cpp</code> - ADME structure for Study 2 (90mg)</li> </ul> <h3>Simulation</h3> <ul> <li><code>[1] sim_csv_file.R</code> - Simulation execution script</li> <li><code>[2] sim_control_making.R</code> - Generate simulation control parameters</li> </ul> <h3>Data</h3> <ul> <li><code>final_data_set_base.csv</code> - Pooled virtual patient dataset (n=1,000)</li> </ul> <h2>Requirements</h2> <ul> <li>R (≥ 4.3.1)</li> <li>mrgsolve</li> <li>tidyverse</li> </ul> <h2>References</h2> <ul> <li>Li J, et al. Population pharmacokinetics of ticagrelor in patients with acute coronary syndromes. Int J Clin Pharmacol Ther. 2016;54:666-674.</li> <li>Röshammar D, et al. Population pharmacokinetics of ticagrelor and AR-C124910XX in patients with prior myocardial infarction. Int J Clin Pharmacol Ther. 2017;55:416-424.</li> </ul> <h2>License</h2> <p>MIT License</p> |
| title | IM-JW/ticagrelor-popPK: v1.0.0 - Initial release |
| url | https://doi.org/10.5281/zenodo.18251968 |