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2026
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| Online Access: | https://doi.org/10.5281/zenodo.18252608 |
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| author | Dr. Sravanthi Gurugubelli |
| author_facet | Dr. Sravanthi Gurugubelli |
| contents | <div> <div> <table> <tbody> <tr> <td> <p><strong>Background:</strong> Rudolph Virchow emphasized the delicacy of internal viscera, and the skin, the body’s largest organ, serves as their protective interface.. Along with preventing mechanical injury and excessive fluid loss, skin provides sensory perception and supports endocrine activity through vitamin D synthesis. Many non-neoplastic dermatoses share overlapping morphologies (macules, papules, plaques, nodules, pustules, and pigmentary changes), so clinically distinct entities may appear similar. Histopathology remains the gold standard for confirmatory diagnosis and for meaningful clinicopathological correlation. <strong>Objective:</strong> To describe the histopathological spectrum of clinically suspected non-neoplastic skin disorders and to assess clinicopathological concordance. <strong>Methods:</strong> This observational study was conducted at NRI Institute of Medical Sciences, Sangivalasa, Visakhapatnam, Andhra Pradesh, India, from April 2020 to October 2022. Consecutive patients with clinically suspected non-neoplastic skin disorders were included (n = 100). A representative 4-mm punch biopsy was obtained from each case, followed by routine fixation and tissue processing. Sections were stained with hematoxylin and eosin and examined microscopically. Final histopathological diagnoses were assigned, grouped into standard non-neoplastic categories, and compared with provisional clinical diagnoses to determine concordance. <strong>Results:</strong> Of 100 biopsied non-neoplastic dermatoses, non-infectious erythematous papulosquamous disorders were most frequent(42%). Infectious lesions comprised 17% (including Hansen’s disease), followed by inflammatory disorders of skin adnexae(9%), pigment disorders(8%), connective tissue disorders(7%), vascular disorders(5%), and cutaneous drug toxicities(4%). Vesiculobullous disorders, vesiculopustular disorders, and genodermatoses each accounted for 3%. Non-infectious granulomatous disorders(1%) and degenerative/perforating diseases(1%) were least common. Overall, clinicopathological concordance was 72%(72/100). <strong>Conclusion:</strong> Non-neoplastic dermatoses often share similar clinical appearances, increasing the risk of misdiagnosis and inappropriate therapy. Histopathology with clinicopathological correlation improves diagnostic precision and guides lesion-specific management, helping to minimize both under and overtreatment.</p> </td> </tr> </tbody> </table> </div> </div> <div></div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18252608 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
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| spellingShingle | Study on the Histomorphological Spectrum of Non-neoplastic Skin Disorders at A tertiary care Centre Dr. Sravanthi Gurugubelli <div> <div> <table> <tbody> <tr> <td> <p><strong>Background:</strong> Rudolph Virchow emphasized the delicacy of internal viscera, and the skin, the body’s largest organ, serves as their protective interface.. Along with preventing mechanical injury and excessive fluid loss, skin provides sensory perception and supports endocrine activity through vitamin D synthesis. Many non-neoplastic dermatoses share overlapping morphologies (macules, papules, plaques, nodules, pustules, and pigmentary changes), so clinically distinct entities may appear similar. Histopathology remains the gold standard for confirmatory diagnosis and for meaningful clinicopathological correlation. <strong>Objective:</strong> To describe the histopathological spectrum of clinically suspected non-neoplastic skin disorders and to assess clinicopathological concordance. <strong>Methods:</strong> This observational study was conducted at NRI Institute of Medical Sciences, Sangivalasa, Visakhapatnam, Andhra Pradesh, India, from April 2020 to October 2022. Consecutive patients with clinically suspected non-neoplastic skin disorders were included (n = 100). A representative 4-mm punch biopsy was obtained from each case, followed by routine fixation and tissue processing. Sections were stained with hematoxylin and eosin and examined microscopically. Final histopathological diagnoses were assigned, grouped into standard non-neoplastic categories, and compared with provisional clinical diagnoses to determine concordance. <strong>Results:</strong> Of 100 biopsied non-neoplastic dermatoses, non-infectious erythematous papulosquamous disorders were most frequent(42%). Infectious lesions comprised 17% (including Hansen’s disease), followed by inflammatory disorders of skin adnexae(9%), pigment disorders(8%), connective tissue disorders(7%), vascular disorders(5%), and cutaneous drug toxicities(4%). Vesiculobullous disorders, vesiculopustular disorders, and genodermatoses each accounted for 3%. Non-infectious granulomatous disorders(1%) and degenerative/perforating diseases(1%) were least common. Overall, clinicopathological concordance was 72%(72/100). <strong>Conclusion:</strong> Non-neoplastic dermatoses often share similar clinical appearances, increasing the risk of misdiagnosis and inappropriate therapy. Histopathology with clinicopathological correlation improves diagnostic precision and guides lesion-specific management, helping to minimize both under and overtreatment.</p> </td> </tr> </tbody> </table> </div> </div> <div></div> |
| title | Study on the Histomorphological Spectrum of Non-neoplastic Skin Disorders at A tertiary care Centre |
| url | https://doi.org/10.5281/zenodo.18252608 |