| _version_ | 1866901041496195072 |
|---|---|
| author | Lázaro-Antón, Leticia Zúñiga-Ripa, Amaia |
| author_facet | Lázaro-Antón, Leticia Zúñiga-Ripa, Amaia |
| contents | <p><span lang="EN-US">The metabolic network includes complete Pentose Phosphate, Entner–Doudoroff, and gluconeogenesis pathways, as well as a complete tricarboxylic acid cycle including a glyoxylate shunt. Gray arrows and gray font indicate peripheral pathways. Metabolites: 1,3,bPG, 1,3 bisphosphoglycerate; KDPG, 2-keto-3-deoxy-phosphogluconate; 2PG, 2-phosphoglycerate; 3PG, 3-phosphoglycerate; 6PGL, 6-P-gluconolactone; 6PG, 6-phosphogluconate; AcCoA, acetyl-coenzyme A; AKG, alpha-ketoglutarate; CIT, citrate; ICIT, isocitrate; DHAP, dihydroxyacetone-P; E4P, erythrose 4-P; F1,6bP, fructose 1,6-bisphosphate; F6P, fructose 6-P; FUM, fumarate; G6P, glucose 6-P; GAP, glyceraldehyde 3-P; G3P, glycerol 3-P; GLX, glyoxylate; MAL, malate; OAA, oxaloacetate; PEP, phosphoenolpyruvate; PYR, pyruvate; R5P, ribose 5-P; RIB5P, ribulose 5-P; S7P, sedoheptulose 7-P; SUC, succinate; SucCoA, succinyl-coenzyme A; X5P, xylulose-5-P. Enzymes: Edd, 6-phospho-D-gluconate dehydratase; Gnd, 6-phosphogluconate dehydrogenase; Pgl, 6-phosphogluconolactonase; Acs, acetyl-coenzyme A synthetase; Acn, aconitate hydratase; Akgdh, alpha-ketoglutarate dehydrogenase; GltA, citrate synthase; Eno, enolase; Fbp/GlpX, fructose 1,6-bisphosphatase; Fba, fructose bisphosphate aldolase; Fum, fumarase; Zwf, glucose 6-P dehydrogenase; Pgi, glucose 6-P isomerase; Gdh, glutamate dehydrogenase; Gapdh, glyceraldehyde 3-P dehydrogenase; GlpD, glycerol 3-P dehydrogenase; GlpK, glycerol kinase; Idh, isocitrate dehydrogenase; AceA, isocitrate lyase; Eda, 2-dehydro-3-deoxy-phosphogluconate aldolase; Ldh, lactate dehydrogenase; Mdh, malate dehydrogenase; AceB, malate synthase; Mae, malic enzyme; PckA, phosphoenolpyruvate carboxykinase; Pgk, phosphoglycerate kinase; Gpm, phosphoglycerate mutase; Pyc, pyruvate carboxylase; Pdh, pyruvate dehydrogenase; Pyk, pyruvate kinase; PpdK, pyruvate phosphate dikinase; Rpi, ribose 5-P isomerase; Rpe, ribulose-5-P-3-epimerase; Sdh, succinate dehydrogenase; Stk, succinyl-coenzyme A synthethase; Tal, transaldolase; Tkt, transketolase; Tpi, triose P isomerase.</span></p> <p><u><span lang="EN-US">References</span></u></p> <p><span lang="EN-US">12. Zúñiga-Ripa A, Barbier T, Lázaro-Antón L, de Miguel MJ, Conde-Álvarez R, Muñoz PM, et al. The fast-growing <em>Brucella suis</em> biovar 5 depends on phosphoenolpyruvate carboxykinase and pyruvate phosphate dikinase but not on Fbp and GlpX fructose-1,6-bisphosphatases or isocitrate lyase for full virulence in laboratory models. Front Microbiol. (2018) 9:641. doi: 10.3389/fmicb.2018.00641</span></p> <p><span lang="EN-US">18. Barbier T, Collard F, Zúñiga-Ripa A, Moriyón I, Godard T, Becker J, et al. Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in <em>Brucella</em>. Proc Natl Acad Sci. (2014) 111:17815–20. doi: 10.1073/pnas.1414622111</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18255200 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Central C metabolic network of Brucella suis 513 [adapted from Barbier et al. (18) and Zúñiga-Ripa et al. (12)] Lázaro-Antón, Leticia Zúñiga-Ripa, Amaia <p><span lang="EN-US">The metabolic network includes complete Pentose Phosphate, Entner–Doudoroff, and gluconeogenesis pathways, as well as a complete tricarboxylic acid cycle including a glyoxylate shunt. Gray arrows and gray font indicate peripheral pathways. Metabolites: 1,3,bPG, 1,3 bisphosphoglycerate; KDPG, 2-keto-3-deoxy-phosphogluconate; 2PG, 2-phosphoglycerate; 3PG, 3-phosphoglycerate; 6PGL, 6-P-gluconolactone; 6PG, 6-phosphogluconate; AcCoA, acetyl-coenzyme A; AKG, alpha-ketoglutarate; CIT, citrate; ICIT, isocitrate; DHAP, dihydroxyacetone-P; E4P, erythrose 4-P; F1,6bP, fructose 1,6-bisphosphate; F6P, fructose 6-P; FUM, fumarate; G6P, glucose 6-P; GAP, glyceraldehyde 3-P; G3P, glycerol 3-P; GLX, glyoxylate; MAL, malate; OAA, oxaloacetate; PEP, phosphoenolpyruvate; PYR, pyruvate; R5P, ribose 5-P; RIB5P, ribulose 5-P; S7P, sedoheptulose 7-P; SUC, succinate; SucCoA, succinyl-coenzyme A; X5P, xylulose-5-P. Enzymes: Edd, 6-phospho-D-gluconate dehydratase; Gnd, 6-phosphogluconate dehydrogenase; Pgl, 6-phosphogluconolactonase; Acs, acetyl-coenzyme A synthetase; Acn, aconitate hydratase; Akgdh, alpha-ketoglutarate dehydrogenase; GltA, citrate synthase; Eno, enolase; Fbp/GlpX, fructose 1,6-bisphosphatase; Fba, fructose bisphosphate aldolase; Fum, fumarase; Zwf, glucose 6-P dehydrogenase; Pgi, glucose 6-P isomerase; Gdh, glutamate dehydrogenase; Gapdh, glyceraldehyde 3-P dehydrogenase; GlpD, glycerol 3-P dehydrogenase; GlpK, glycerol kinase; Idh, isocitrate dehydrogenase; AceA, isocitrate lyase; Eda, 2-dehydro-3-deoxy-phosphogluconate aldolase; Ldh, lactate dehydrogenase; Mdh, malate dehydrogenase; AceB, malate synthase; Mae, malic enzyme; PckA, phosphoenolpyruvate carboxykinase; Pgk, phosphoglycerate kinase; Gpm, phosphoglycerate mutase; Pyc, pyruvate carboxylase; Pdh, pyruvate dehydrogenase; Pyk, pyruvate kinase; PpdK, pyruvate phosphate dikinase; Rpi, ribose 5-P isomerase; Rpe, ribulose-5-P-3-epimerase; Sdh, succinate dehydrogenase; Stk, succinyl-coenzyme A synthethase; Tal, transaldolase; Tkt, transketolase; Tpi, triose P isomerase.</span></p> <p><u><span lang="EN-US">References</span></u></p> <p><span lang="EN-US">12. Zúñiga-Ripa A, Barbier T, Lázaro-Antón L, de Miguel MJ, Conde-Álvarez R, Muñoz PM, et al. The fast-growing <em>Brucella suis</em> biovar 5 depends on phosphoenolpyruvate carboxykinase and pyruvate phosphate dikinase but not on Fbp and GlpX fructose-1,6-bisphosphatases or isocitrate lyase for full virulence in laboratory models. Front Microbiol. (2018) 9:641. doi: 10.3389/fmicb.2018.00641</span></p> <p><span lang="EN-US">18. Barbier T, Collard F, Zúñiga-Ripa A, Moriyón I, Godard T, Becker J, et al. Erythritol feeds the pentose phosphate pathway via three new isomerases leading to D-erythrose-4-phosphate in <em>Brucella</em>. Proc Natl Acad Sci. (2014) 111:17815–20. doi: 10.1073/pnas.1414622111</span></p> |
| title | Central C metabolic network of Brucella suis 513 [adapted from Barbier et al. (18) and Zúñiga-Ripa et al. (12)] |
| url | https://doi.org/10.5281/zenodo.18255200 |