Combinatorial Therapeutic Strategies and Multi-Modal Synergies for Functional HIV Remission: Modeling and Optimization of Integrated Therapeutic Sequences
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2026
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| _version_ | 1866901812455407616 |
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| author | Ndenga, Barack |
| author_facet | Ndenga, Barack |
| contents | <p>The persistence of HIV-1 despite effective antiretroviral therapy (ART) reveals a fundamental biological truth: single-modality interventions are architecturally insufficient for achieving a durable cure or remission. HIV latency, immune dysfunction, and viral rebound are governed by interconnected systems that cannot be dismantled in isolation. In this article, I examine the paradigm of combinatorial therapeutic strategies that integrate pharmacological, immunological, genetic, and computational modalities. I emphasize the rational design, critical temporal sequencing, and systems-level optimization required to transform isolated interventions into coherent, synergistic therapeutic ecosystems. This work argues that the future of HIV cure research lies not in a singular 'magic bullet,' but in the precision orchestration of multi-modal approaches to achieve realistic, functional remission.</p> <p> </p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18263572 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
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| spellingShingle | Combinatorial Therapeutic Strategies and Multi-Modal Synergies for Functional HIV Remission: Modeling and Optimization of Integrated Therapeutic Sequences Ndenga, Barack HIV cure,Functional remission,Combinatorial therapy,Therapeutic synergy,Multi-modal intervention,Temporal sequencing,Systems optimization,Computational modeling,Shock and Kill,Treatment interruption,Latency reversing agents (LRAs),CAR-T cells,Broadly neutralizing antibodies (bNAbs),Therapeutic vaccine,Precision medicine <p>The persistence of HIV-1 despite effective antiretroviral therapy (ART) reveals a fundamental biological truth: single-modality interventions are architecturally insufficient for achieving a durable cure or remission. HIV latency, immune dysfunction, and viral rebound are governed by interconnected systems that cannot be dismantled in isolation. In this article, I examine the paradigm of combinatorial therapeutic strategies that integrate pharmacological, immunological, genetic, and computational modalities. I emphasize the rational design, critical temporal sequencing, and systems-level optimization required to transform isolated interventions into coherent, synergistic therapeutic ecosystems. This work argues that the future of HIV cure research lies not in a singular 'magic bullet,' but in the precision orchestration of multi-modal approaches to achieve realistic, functional remission.</p> <p> </p> |
| title | Combinatorial Therapeutic Strategies and Multi-Modal Synergies for Functional HIV Remission: Modeling and Optimization of Integrated Therapeutic Sequences |
| topic | HIV cure,Functional remission,Combinatorial therapy,Therapeutic synergy,Multi-modal intervention,Temporal sequencing,Systems optimization,Computational modeling,Shock and Kill,Treatment interruption,Latency reversing agents (LRAs),CAR-T cells,Broadly neutralizing antibodies (bNAbs),Therapeutic vaccine,Precision medicine |
| url | https://doi.org/10.5281/zenodo.18263572 |