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| Format: | Recurso digital |
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Zenodo
2026
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| Online Access: | https://doi.org/10.5281/zenodo.18263572 |
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Table of Contents:
- <p>The persistence of HIV-1 despite effective antiretroviral therapy (ART) reveals a fundamental biological truth: single-modality interventions are architecturally insufficient for achieving a durable cure or remission. HIV latency, immune dysfunction, and viral rebound are governed by interconnected systems that cannot be dismantled in isolation. In this article, I examine the paradigm of combinatorial therapeutic strategies that integrate pharmacological, immunological, genetic, and computational modalities. I emphasize the rational design, critical temporal sequencing, and systems-level optimization required to transform isolated interventions into coherent, synergistic therapeutic ecosystems. This work argues that the future of HIV cure research lies not in a singular 'magic bullet,' but in the precision orchestration of multi-modal approaches to achieve realistic, functional remission.</p> <p> </p>