NEUROPLASTICITY AND REHABILITATION AFTER STROKE: EVIDENCE-BASED MECHANISMS AND THERAPEUTIC APPROACHES FOR ENHANCING FUNCTIONAL RECOVERY
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2026
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| author | Dr. Rashid Usman, Dr Muhammad Arif, Dr. Muhammad Fahad Khaliq, Dr Maria shaikh |
| author_facet | Dr. Rashid Usman, Dr Muhammad Arif, Dr. Muhammad Fahad Khaliq, Dr Maria shaikh |
| contents | <div> <p><strong><em><span>Background</span></em></strong><em><span>: Stroke is a leading cause of long-term disability worldwide and places a substantial burden on individuals, families, and healthcare systems. Functional recovery after stroke is largely mediated by neuroplasticity, defined as the brain’s capacity to reorganize its structural and functional networks in response to injury and experience. </span></em></p> <p><strong><em><span>Aim</span></em></strong><em><span>: This study aims to synthesize high-quality experimental and clinical evidence on neuroplasticity-based rehabilitation interventions and to evaluate their effectiveness in enhancing motor and functional recovery following stroke.</span></em></p> <p><strong><em><span>Methodology</span></em></strong><em><span>: An evidence-based review was conducted using experimental and clinical studies indexed in SCIE databases. Randomized controlled trials evaluating neuroplasticity-oriented rehabilitation were included. Interventions examined included constraint-induced movement therapy, task-specific training, virtual reality-based rehabilitation, robotic-assisted therapy, and non-invasive brain stimulation.<br><strong>Results</strong>: Neuroplasticity-driven rehabilitation interventions consistently demonstrated significant and sustained improvements in motor and functional outcomes. Early initiation, high training intensity, and task-specific practice were associated with enhanced adaptive cortical reorganization.<br><strong>Conclusion</strong>: Neuroplasticity-based rehabilitation is fundamental to post-stroke recovery. Early, intensive, and task-oriented interventions significantly enhance outcomes and should be integrated into standard care.<br><strong>Keywords</strong>: Stroke; Neuroplasticity; Rehabilitation; Motor Recovery; Constraint-Induced Movement Therapy; Virtual Reality</span></em></p> </div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18303257 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
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| spellingShingle | NEUROPLASTICITY AND REHABILITATION AFTER STROKE: EVIDENCE-BASED MECHANISMS AND THERAPEUTIC APPROACHES FOR ENHANCING FUNCTIONAL RECOVERY Dr. Rashid Usman, Dr Muhammad Arif, Dr. Muhammad Fahad Khaliq, Dr Maria shaikh <div> <p><strong><em><span>Background</span></em></strong><em><span>: Stroke is a leading cause of long-term disability worldwide and places a substantial burden on individuals, families, and healthcare systems. Functional recovery after stroke is largely mediated by neuroplasticity, defined as the brain’s capacity to reorganize its structural and functional networks in response to injury and experience. </span></em></p> <p><strong><em><span>Aim</span></em></strong><em><span>: This study aims to synthesize high-quality experimental and clinical evidence on neuroplasticity-based rehabilitation interventions and to evaluate their effectiveness in enhancing motor and functional recovery following stroke.</span></em></p> <p><strong><em><span>Methodology</span></em></strong><em><span>: An evidence-based review was conducted using experimental and clinical studies indexed in SCIE databases. Randomized controlled trials evaluating neuroplasticity-oriented rehabilitation were included. Interventions examined included constraint-induced movement therapy, task-specific training, virtual reality-based rehabilitation, robotic-assisted therapy, and non-invasive brain stimulation.<br><strong>Results</strong>: Neuroplasticity-driven rehabilitation interventions consistently demonstrated significant and sustained improvements in motor and functional outcomes. Early initiation, high training intensity, and task-specific practice were associated with enhanced adaptive cortical reorganization.<br><strong>Conclusion</strong>: Neuroplasticity-based rehabilitation is fundamental to post-stroke recovery. Early, intensive, and task-oriented interventions significantly enhance outcomes and should be integrated into standard care.<br><strong>Keywords</strong>: Stroke; Neuroplasticity; Rehabilitation; Motor Recovery; Constraint-Induced Movement Therapy; Virtual Reality</span></em></p> </div> |
| title | NEUROPLASTICITY AND REHABILITATION AFTER STROKE: EVIDENCE-BASED MECHANISMS AND THERAPEUTIC APPROACHES FOR ENHANCING FUNCTIONAL RECOVERY |
| url | https://doi.org/10.5281/zenodo.18303257 |