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| Format: | Recurso digital |
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Zenodo
1990
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| Online Access: | https://doi.org/10.5281/zenodo.18337764 |
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| _version_ | 1866901891840999424 |
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| author | C. Richard M.A. Cuadrado M. Prieto J. Batlle M.F. López Fernández M.L. Rodríguez Salazar C. Bello M. Recio T. Santoro GOMEZ CASARES, MARIA TERESA A. Zubizarreta |
| author_facet | C. Richard M.A. Cuadrado M. Prieto J. Batlle M.F. López Fernández M.L. Rodríguez Salazar C. Bello M. Recio T. Santoro GOMEZ CASARES, MARIA TERESA A. Zubizarreta |
| contents | <p>This article reports a case of acquired von Willebrand disease (AvWD) associated with IgA lambda multiple myeloma. No circulating inhibitor was detected. Multimeric analysis showed a decrease in all-sized von Willebrand factor (vWF) multimers with a type IA pattern. After DDAVP infusion, larger vWF multimers appeared transiently in plasma and were progressively cleared, suggesting increased removal from circulation. Indirect immunofluorescence using a monoclonal antibody demonstrated selective absorption of vWF into myelomatous plasma cells. The findings support a new pathophysiological mechanism of AvWD in multiple myeloma and potentially other lymphoproliferative disorders.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18337764 |
| institution | Zenodo |
| language | |
| publishDate | 1990 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Acquired von Willebrand Disease in Multiple Myeloma Secondary to Absorption of von Willebrand Factor by Plasma Cells C. Richard M.A. Cuadrado M. Prieto J. Batlle M.F. López Fernández M.L. Rodríguez Salazar C. Bello M. Recio T. Santoro GOMEZ CASARES, MARIA TERESA A. Zubizarreta <p>This article reports a case of acquired von Willebrand disease (AvWD) associated with IgA lambda multiple myeloma. No circulating inhibitor was detected. Multimeric analysis showed a decrease in all-sized von Willebrand factor (vWF) multimers with a type IA pattern. After DDAVP infusion, larger vWF multimers appeared transiently in plasma and were progressively cleared, suggesting increased removal from circulation. Indirect immunofluorescence using a monoclonal antibody demonstrated selective absorption of vWF into myelomatous plasma cells. The findings support a new pathophysiological mechanism of AvWD in multiple myeloma and potentially other lymphoproliferative disorders.</p> |
| title | Acquired von Willebrand Disease in Multiple Myeloma Secondary to Absorption of von Willebrand Factor by Plasma Cells |
| url | https://doi.org/10.5281/zenodo.18337764 |