Salvato in:
| Autori principali: | , , , , , , , , , , |
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| Natura: | Recurso digital |
| Lingua: | |
| Pubblicazione: |
Zenodo
1990
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| Accesso online: | https://doi.org/10.5281/zenodo.18337764 |
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Sommario:
- <p>This article reports a case of acquired von Willebrand disease (AvWD) associated with IgA lambda multiple myeloma. No circulating inhibitor was detected. Multimeric analysis showed a decrease in all-sized von Willebrand factor (vWF) multimers with a type IA pattern. After DDAVP infusion, larger vWF multimers appeared transiently in plasma and were progressively cleared, suggesting increased removal from circulation. Indirect immunofluorescence using a monoclonal antibody demonstrated selective absorption of vWF into myelomatous plasma cells. The findings support a new pathophysiological mechanism of AvWD in multiple myeloma and potentially other lymphoproliferative disorders.</p>