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| Format: | Recurso digital |
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Zenodo
2026
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| Accès en ligne: | https://doi.org/10.5281/zenodo.18352689 |
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| _version_ | 1866901740421382144 |
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| author | Parker, Steven |
| author_facet | Parker, Steven |
| contents | <p>This study reevaluates the autosomal genetic structure of Ashkenazi Jewish populations by examining the effects of reference-population choice on population genetic inference. Previous analyses have frequently modeled “Europe” using Northern Italian, Tuscan, or Sardinian proxies while omitting Southern Italian and central Mediterranean populations. This reference truncation systematically biases results toward an apparent Levant-leaning or intermediate position.</p> <p>When Southern European comparators are included, Ashkenazi autosomal affinities shift substantially, altering inferred relationships with both European and Near Eastern populations. Using calibrated pairwise FST distances, genotype-based affinity comparisons, and qpAdm admixture modeling, the study demonstrates that Ashkenazi Jews cluster most closely with Southern European and central Mediterranean populations under full regional sampling.</p> <p>Key findings include:</p> <ul> <li> <p>Autosomal genetic distances between Ashkenazi Jews and Southern Italians or Maltese are comparable to distances observed between well-established regional population pairs with shared ancestry.</p> </li> <li> <p>Distances to Levantine populations remain consistently higher across modeling approaches.</p> </li> <li> <p>Admixture models constrained to Northern Italian European sources generate artifacts that do not persist when Mediterranean diversity is properly represented.</p> </li> <li> <p>Uniparental lineage distributions and historical demographic context independently align with a central Mediterranean framework.</p> </li> </ul> <p>Together, these results show that prior Levant-leaning interpretations arise primarily from reference-population bias rather than underlying genetic structure. The study highlights the critical role of reference design in population genetics and provides a corrected framework for interpreting Ashkenazi autosomal ancestry. The complete manuscript and supplementary materials are provided to support transparency and reproducibility.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18352689 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Reference Population Design and the Illusion of Genetic Intermediacy in Mediterranean Population Models Parker, Steven <p>This study reevaluates the autosomal genetic structure of Ashkenazi Jewish populations by examining the effects of reference-population choice on population genetic inference. Previous analyses have frequently modeled “Europe” using Northern Italian, Tuscan, or Sardinian proxies while omitting Southern Italian and central Mediterranean populations. This reference truncation systematically biases results toward an apparent Levant-leaning or intermediate position.</p> <p>When Southern European comparators are included, Ashkenazi autosomal affinities shift substantially, altering inferred relationships with both European and Near Eastern populations. Using calibrated pairwise FST distances, genotype-based affinity comparisons, and qpAdm admixture modeling, the study demonstrates that Ashkenazi Jews cluster most closely with Southern European and central Mediterranean populations under full regional sampling.</p> <p>Key findings include:</p> <ul> <li> <p>Autosomal genetic distances between Ashkenazi Jews and Southern Italians or Maltese are comparable to distances observed between well-established regional population pairs with shared ancestry.</p> </li> <li> <p>Distances to Levantine populations remain consistently higher across modeling approaches.</p> </li> <li> <p>Admixture models constrained to Northern Italian European sources generate artifacts that do not persist when Mediterranean diversity is properly represented.</p> </li> <li> <p>Uniparental lineage distributions and historical demographic context independently align with a central Mediterranean framework.</p> </li> </ul> <p>Together, these results show that prior Levant-leaning interpretations arise primarily from reference-population bias rather than underlying genetic structure. The study highlights the critical role of reference design in population genetics and provides a corrected framework for interpreting Ashkenazi autosomal ancestry. The complete manuscript and supplementary materials are provided to support transparency and reproducibility.</p> |
| title | Reference Population Design and the Illusion of Genetic Intermediacy in Mediterranean Population Models |
| url | https://doi.org/10.5281/zenodo.18352689 |