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| Format: | Recurso digital |
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Zenodo
2026
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| Online Access: | https://doi.org/10.5281/zenodo.18450711 |
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Table of Contents:
- <p>Cerebral perfusion under hypertensive conditions presents paradoxes not fully explained by conventional pressure-flow models. This manuscript introduces a wavemechanical framework derived from the de Broglie relation (λp = h), establishing<br>pressure along each spatial axis as P_i = 1/2ρv^2 (cosθ_i), where θ_i is the angle between the angular momentum vector h and axis i, and density ρ = δm · (δψ)3 emerges from wave compaction geometry. Total pressure P_T = 1/2ρv^2(Summation cos θ_i) governs perfusion distribution across vascular branches.<br>As mean arterial pressure (MAP) increases, flow alignment causes θ_i → π/2 for<br>transverse axes, leading to selective pressure collapse along perforator directions despite<br>rising global cerebral blood volume (CBV). This mechanism explains the paradoxical<br>ischemic MRI patterns observed in hypertensive encephalopathy, where cortical vessels<br>remain spared while deep and superficial perforators sustain injury.<br>By modeling perfusion as wave energy projection across vascular axes, this framework<br>provides a novel structural lens on autoregulatory failure, perfusion collapse, and regional vulnerability</p>