Evaluation effects of corticosteroids therapy on bone mineral density in postmenopausal woman patients with rheumatoid arthritis
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| Format: | Recurso digital |
| Language: | English |
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2008
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| _version_ | 1866902115379576832 |
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| author | Vasić, B Popović, Budimir Milenovic, Natasa |
| author_facet | Vasić, B Popović, Budimir Milenovic, Natasa |
| contents | <p>Introduction- Rheumatoid arthritis (RA) as autoimmune, inflammatory arthropathy required specific treatment which includes usage of glikocorticoides which may influenced on Bone Mineral Density (BMD. Especially vulnerable category is postmenopausal woman. Aim- The aim of study was to evaluate effect of corticosteroids therapy on BMD in postmenopausal female patients with RA. Material and methods- We examined 150 female patients 58.04 years old (45–74 years) who suffered from RA 3.55 years (1–10 years. All patients were in post menopause more than 2 years. Analysis of BMD was performed with “Sahara” ultrasound osteodesitometry. Results- Stage or RA changes was classified with Stein-Brocker`s criteria and we found that 53.06% of our patients were in Grade 1 anatomical classification but 51.02% were in Grade 2 functional classification, that was indicated worse functional condition of our patient, which was supported with our found statistically significant correlation (r=0.4217; p=0.003) between age and period of duration disease. Average T–score was -2.24 (-3.0 to 1.7) and Z-score was -0.87 (-2.1 to<br>1.2) which was shown high level of osteopenia. But 59.18% of our patients had T- score lower than -2.5 which was shown high level of osteoporosis. Average period of application of corticosteroids was 2.69 years and in 46.94% of patients applied dose was 5 mg/day and in 34.69% was 10 mg/day. We found statistically significant correlation (r=0.4620; p=0.001) between age and period of application also between period of duration of disease and period of application (r=0.8731, p=0.000). We found statistically significant correlation between period of application and T- score (r=0.3544; p=0.012) which indicated that corticosteroid therapy negatively influenced on BMD. Also we found statistically significant reduction of BMD (r=-0.3249; p=0.023) which was in correlation with duration of disease. Canonical analyses showed existing canonical function (Chi square=3.8206; p=0.0486) between applied dose and T-score which indicate higher influenced of higher dose on reduction BMD. Conclusion- We can conclude that corticosteroids application in treatment RA could potential negatively influenced on BMD. Because of that we recommended that antiresoprptive drug has to be including as regular therapy of RA for the same patients.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18486138 |
| institution | Zenodo |
| language | eng |
| publishDate | 2008 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Evaluation effects of corticosteroids therapy on bone mineral density in postmenopausal woman patients with rheumatoid arthritis Vasić, B Popović, Budimir Milenovic, Natasa Arthritis, Rheumatoid Rheumatoid arthritis bone mineral density corticosteroids Postmenopause Bone Density <p>Introduction- Rheumatoid arthritis (RA) as autoimmune, inflammatory arthropathy required specific treatment which includes usage of glikocorticoides which may influenced on Bone Mineral Density (BMD. Especially vulnerable category is postmenopausal woman. Aim- The aim of study was to evaluate effect of corticosteroids therapy on BMD in postmenopausal female patients with RA. Material and methods- We examined 150 female patients 58.04 years old (45–74 years) who suffered from RA 3.55 years (1–10 years. All patients were in post menopause more than 2 years. Analysis of BMD was performed with “Sahara” ultrasound osteodesitometry. Results- Stage or RA changes was classified with Stein-Brocker`s criteria and we found that 53.06% of our patients were in Grade 1 anatomical classification but 51.02% were in Grade 2 functional classification, that was indicated worse functional condition of our patient, which was supported with our found statistically significant correlation (r=0.4217; p=0.003) between age and period of duration disease. Average T–score was -2.24 (-3.0 to 1.7) and Z-score was -0.87 (-2.1 to<br>1.2) which was shown high level of osteopenia. But 59.18% of our patients had T- score lower than -2.5 which was shown high level of osteoporosis. Average period of application of corticosteroids was 2.69 years and in 46.94% of patients applied dose was 5 mg/day and in 34.69% was 10 mg/day. We found statistically significant correlation (r=0.4620; p=0.001) between age and period of application also between period of duration of disease and period of application (r=0.8731, p=0.000). We found statistically significant correlation between period of application and T- score (r=0.3544; p=0.012) which indicated that corticosteroid therapy negatively influenced on BMD. Also we found statistically significant reduction of BMD (r=-0.3249; p=0.023) which was in correlation with duration of disease. Canonical analyses showed existing canonical function (Chi square=3.8206; p=0.0486) between applied dose and T-score which indicate higher influenced of higher dose on reduction BMD. Conclusion- We can conclude that corticosteroids application in treatment RA could potential negatively influenced on BMD. Because of that we recommended that antiresoprptive drug has to be including as regular therapy of RA for the same patients.</p> |
| title | Evaluation effects of corticosteroids therapy on bone mineral density in postmenopausal woman patients with rheumatoid arthritis |
| topic | Arthritis, Rheumatoid Rheumatoid arthritis bone mineral density corticosteroids Postmenopause Bone Density |
| url | https://doi.org/10.5281/zenodo.18486138 |