Salvato in:
| Autori principali: | , , , , , |
|---|---|
| Natura: | Recurso digital |
| Lingua: | |
| Pubblicazione: |
Zenodo
2020
|
| Soggetti: | |
| Accesso online: | https://doi.org/10.5281/zenodo.18656318 |
| Tags: |
Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne!!
|
| _version_ | 1866901215465439232 |
|---|---|
| author | C. Shanmathi P. Ponmurugan N. Karthik M. Anita A. Ezhilarasu A. Rohini |
| author_facet | C. Shanmathi P. Ponmurugan N. Karthik M. Anita A. Ezhilarasu A. Rohini |
| contents | The current examination assessed the adequacy of hostile to viral compounds against the objective protein, Spike protein of COVID19 utilizing in silico approach. Structure based docking studies was performed using PyRx 8.0 tool to retrieve potential candidates with high affinities binding against antiviral compound models with several targeted proteins repositories. The chosen target protein was 6LU7. Molecular docking was carried out using various anti-viral compounds with the target protein of microorganisms.Free vitality of restricting was recorded for the compound with its objective. Nine different compounds were docked with the target protein, within which was found to own higher binding affinity. Therefore, the current study plays a guiding role in developing new inhibitors with better binding affinities with the virulent protein of pathogens, followed by invention of novel drug to treat bacterial infections. |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18656318 |
| institution | Zenodo |
| language | |
| publishDate | 2020 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | In Silico Analysis of Various Antiviral Compounds Against Spike Protein of COVID 19 using Docking Methods C. Shanmathi P. Ponmurugan N. Karthik M. Anita A. Ezhilarasu A. Rohini Spike protein COVID 19 PyRx8.0 The current examination assessed the adequacy of hostile to viral compounds against the objective protein, Spike protein of COVID19 utilizing in silico approach. Structure based docking studies was performed using PyRx 8.0 tool to retrieve potential candidates with high affinities binding against antiviral compound models with several targeted proteins repositories. The chosen target protein was 6LU7. Molecular docking was carried out using various anti-viral compounds with the target protein of microorganisms.Free vitality of restricting was recorded for the compound with its objective. Nine different compounds were docked with the target protein, within which was found to own higher binding affinity. Therefore, the current study plays a guiding role in developing new inhibitors with better binding affinities with the virulent protein of pathogens, followed by invention of novel drug to treat bacterial infections. |
| title | In Silico Analysis of Various Antiviral Compounds Against Spike Protein of COVID 19 using Docking Methods |
| topic | Spike protein COVID 19 PyRx8.0 |
| url | https://doi.org/10.5281/zenodo.18656318 |