THE INTESTINAL ECOSYSTEM IN NEUROINFLAMMATION AND NEUROPROTECTION: MECHANISTIC INSIGHTS AND EMERGING EVIDENCE WITH RECENT ADVANCEMENTS
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| Sprache: | Englisch |
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2026
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| author | Vinjavarapu L. Anusha*, L. Samatha Sri1, K. Jahnavi1, Mounika1, Sirisha1, Pardhu1, Roddick1, A. Lakshmisai Sri1, K. Naga Venkatasatyasai Himaja1, P. Lakshmi Narayana1, G. Sri Pavani1 |
| author_facet | Vinjavarapu L. Anusha*, L. Samatha Sri1, K. Jahnavi1, Mounika1, Sirisha1, Pardhu1, Roddick1, A. Lakshmisai Sri1, K. Naga Venkatasatyasai Himaja1, P. Lakshmi Narayana1, G. Sri Pavani1 |
| contents | <p><span lang="EN-GB">The intestinal ecosystem (gut microbiota, intestinal mucosa, intestinal immune cells, neuronal components (enteric nervous system and vagus nerve), and metabolic products of microbes) has a potent influence on homeostasis of the central nervous system (CNS). The mounting preclinical and clinical evidence is pointing towards the involvement of gut-derived signals in both neuroinflammatorysignaling and neuroprotectivesignaling to exacerbate neurological disease and maintain neuronal activity respectively. It is a survey of mechanistic knowledge (barrier integrity, immune modulation, microbial metabolites, vagal and enteric signaling), clinical and experimental evidence on large-scale disorders (Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, autism spectrum disorder), and new ways of therapeutic intervention (dietary modulation, psychobiotics, fecal microbiota transplantation, metabolites and receptor-targeted drugs, and neuromodulation). We present unanswered questions and give a roadmap of a translational </span><span>research and clinical trials to implement the intestinal environment to shield the brain.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18660009 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | THE INTESTINAL ECOSYSTEM IN NEUROINFLAMMATION AND NEUROPROTECTION: MECHANISTIC INSIGHTS AND EMERGING EVIDENCE WITH RECENT ADVANCEMENTS Vinjavarapu L. Anusha*, L. Samatha Sri1, K. Jahnavi1, Mounika1, Sirisha1, Pardhu1, Roddick1, A. Lakshmisai Sri1, K. Naga Venkatasatyasai Himaja1, P. Lakshmi Narayana1, G. Sri Pavani1 <p><span lang="EN-GB">The intestinal ecosystem (gut microbiota, intestinal mucosa, intestinal immune cells, neuronal components (enteric nervous system and vagus nerve), and metabolic products of microbes) has a potent influence on homeostasis of the central nervous system (CNS). The mounting preclinical and clinical evidence is pointing towards the involvement of gut-derived signals in both neuroinflammatorysignaling and neuroprotectivesignaling to exacerbate neurological disease and maintain neuronal activity respectively. It is a survey of mechanistic knowledge (barrier integrity, immune modulation, microbial metabolites, vagal and enteric signaling), clinical and experimental evidence on large-scale disorders (Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, autism spectrum disorder), and new ways of therapeutic intervention (dietary modulation, psychobiotics, fecal microbiota transplantation, metabolites and receptor-targeted drugs, and neuromodulation). We present unanswered questions and give a roadmap of a translational </span><span>research and clinical trials to implement the intestinal environment to shield the brain.</span></p> |
| title | THE INTESTINAL ECOSYSTEM IN NEUROINFLAMMATION AND NEUROPROTECTION: MECHANISTIC INSIGHTS AND EMERGING EVIDENCE WITH RECENT ADVANCEMENTS |
| url | https://doi.org/10.5281/zenodo.18660009 |