THE ASSOCIATION BETWEEN VITAMIN B DEFICIENCY AND COGNITIVE IMPAIRMENT AMONG ELDERLY PATIENTS WITH ALZHEIMER'S AND VASCULAR DEMENTIA
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2026
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| _version_ | 1866901586364596224 |
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| author | Valkova M. |
| author_facet | Valkova M. |
| contents | <p><span lang="EN-US">Vitamin B 12 deficiency (VitB12def.) is frequent among elderly patients. The aim of our study was to examine the effect of Vit.B12def. on cognitive decline among patients with cognitive impairment due to Alzheimer’s disease (AD), small vessels disease (SVD) and mixed (vascular and Alzheimer’s) dementia (MD).</span></p> <p><span lang="EN-US">Material and methods: We examined 49 patients with Vit.B12def. (on average age of 77.76±6.41 years, 18 males and 31 females, 17 with AD, 13 with SVD and 19 with MD) and 97 patients with normal Vit.B12 levels (on average age of 76.07±7.97, 28 males and 66 females, 21 with AD, 43 with SVD and 33 with MD) twice (with interval of 2 years) via Mini Mental State Examination (MMSE), Isaac’s Set Test (IST), Literal fluency Test (LFT), Clock Drawing Test (CDT), 10 Words, Digit Symbol Substitution test (DSST 90sec), Digit Span Test (DST forward and backward) and 21 Hamilton Depression Scale. All results were interpreted at 95% confidential level.</span></p> <p><span lang="EN-US">Results: Regression analysis showed not linear but square root associations between Vit.B12 level and recognition. CDT, DST forward and DSST, exponential correlations between Vit.B12 and recognition at the second examination and reciprocal correlation with IST at the second examination.</span></p> <p><span lang="EN-US">Conclusions: Vit.B12def. is with high prevalence among elderly with AD, SVD and MD. It might lead to additional domain specific cognitive decline (executive functioning, hippocampal memory and visual-special abilities). The association between the levels of Vit.B12 and cognitive performances is non-linear, mostly square root. Patients with such dementias should be examined for Vit.B12def. and should be adequately treated.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18677797 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | THE ASSOCIATION BETWEEN VITAMIN B DEFICIENCY AND COGNITIVE IMPAIRMENT AMONG ELDERLY PATIENTS WITH ALZHEIMER'S AND VASCULAR DEMENTIA Valkova M. cognitive impairment, Vitamin B 12 deficiency, Alzheimer's disease, small vessel disease, mixed dementia. <p><span lang="EN-US">Vitamin B 12 deficiency (VitB12def.) is frequent among elderly patients. The aim of our study was to examine the effect of Vit.B12def. on cognitive decline among patients with cognitive impairment due to Alzheimer’s disease (AD), small vessels disease (SVD) and mixed (vascular and Alzheimer’s) dementia (MD).</span></p> <p><span lang="EN-US">Material and methods: We examined 49 patients with Vit.B12def. (on average age of 77.76±6.41 years, 18 males and 31 females, 17 with AD, 13 with SVD and 19 with MD) and 97 patients with normal Vit.B12 levels (on average age of 76.07±7.97, 28 males and 66 females, 21 with AD, 43 with SVD and 33 with MD) twice (with interval of 2 years) via Mini Mental State Examination (MMSE), Isaac’s Set Test (IST), Literal fluency Test (LFT), Clock Drawing Test (CDT), 10 Words, Digit Symbol Substitution test (DSST 90sec), Digit Span Test (DST forward and backward) and 21 Hamilton Depression Scale. All results were interpreted at 95% confidential level.</span></p> <p><span lang="EN-US">Results: Regression analysis showed not linear but square root associations between Vit.B12 level and recognition. CDT, DST forward and DSST, exponential correlations between Vit.B12 and recognition at the second examination and reciprocal correlation with IST at the second examination.</span></p> <p><span lang="EN-US">Conclusions: Vit.B12def. is with high prevalence among elderly with AD, SVD and MD. It might lead to additional domain specific cognitive decline (executive functioning, hippocampal memory and visual-special abilities). The association between the levels of Vit.B12 and cognitive performances is non-linear, mostly square root. Patients with such dementias should be examined for Vit.B12def. and should be adequately treated.</span></p> |
| title | THE ASSOCIATION BETWEEN VITAMIN B DEFICIENCY AND COGNITIVE IMPAIRMENT AMONG ELDERLY PATIENTS WITH ALZHEIMER'S AND VASCULAR DEMENTIA |
| topic | cognitive impairment, Vitamin B 12 deficiency, Alzheimer's disease, small vessel disease, mixed dementia. |
| url | https://doi.org/10.5281/zenodo.18677797 |