SYNTHESIS OF TRIAZOLE BASED MOLECULAR HYBRIDS AS POTENT ANTIOXIDANT AGENTS
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| Natura: | Recurso digital |
| Lingua: | inglese |
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Zenodo
2026
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| _version_ | 1866901347552460800 |
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| author | Somasekhar Tiruveedhula, Radha Krishna Muniganti, Surinderpal Singh, Hemambika Sadasivuni, Kiran Kumar Tatapudi |
| author_facet | Somasekhar Tiruveedhula, Radha Krishna Muniganti, Surinderpal Singh, Hemambika Sadasivuni, Kiran Kumar Tatapudi |
| contents | <p>ABSTRACT</p> <p>Motivated by the notable pharmacological and biological significance of triazole hybrids, we<br>developed a straightforward synthetic approach for a series of novel (4-(2-fluoro-4-(1H-1,2,3-<br>triazol-1-yl)phenyl)piperazin-1-yl)ketone derivatives (7a–j) and evaluated their in vitro<br>antioxidant activities. The synthesized compounds were characterized using various<br>spectroscopic techniques, including 1H NMR, 13C NMR, IR, and LC-MS, and the obtained<br>data were in good agreement with the proposed molecular structures. Antioxidant screening<br>results indicated that the synthesized compounds exhibited appreciable antioxidant activity.<br>Among them, compounds 7j and 7b showed the highest and lowest antioxidant activities,<br>respectively, at concentrations of 100, 50, and 25 μg. In contrast, compounds 7f and 7a<br>demonstrated the maximum and minimum antioxidant activities, respectively, at a<br>concentration of 200 μg, while compound 7c exhibited nearly comparable activity at this<br>concentration. Notably, all remaining compounds, except 7a and 7b, displayed antioxidant<br>activity exceeding 40% at the 200 μg concentration.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18770476 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | SYNTHESIS OF TRIAZOLE BASED MOLECULAR HYBRIDS AS POTENT ANTIOXIDANT AGENTS Somasekhar Tiruveedhula, Radha Krishna Muniganti, Surinderpal Singh, Hemambika Sadasivuni, Kiran Kumar Tatapudi Piperazine, Triazoles, Molecular hybridization, anti-oxidant activity, DPPH. <p>ABSTRACT</p> <p>Motivated by the notable pharmacological and biological significance of triazole hybrids, we<br>developed a straightforward synthetic approach for a series of novel (4-(2-fluoro-4-(1H-1,2,3-<br>triazol-1-yl)phenyl)piperazin-1-yl)ketone derivatives (7a–j) and evaluated their in vitro<br>antioxidant activities. The synthesized compounds were characterized using various<br>spectroscopic techniques, including 1H NMR, 13C NMR, IR, and LC-MS, and the obtained<br>data were in good agreement with the proposed molecular structures. Antioxidant screening<br>results indicated that the synthesized compounds exhibited appreciable antioxidant activity.<br>Among them, compounds 7j and 7b showed the highest and lowest antioxidant activities,<br>respectively, at concentrations of 100, 50, and 25 μg. In contrast, compounds 7f and 7a<br>demonstrated the maximum and minimum antioxidant activities, respectively, at a<br>concentration of 200 μg, while compound 7c exhibited nearly comparable activity at this<br>concentration. Notably, all remaining compounds, except 7a and 7b, displayed antioxidant<br>activity exceeding 40% at the 200 μg concentration.</p> |
| title | SYNTHESIS OF TRIAZOLE BASED MOLECULAR HYBRIDS AS POTENT ANTIOXIDANT AGENTS |
| topic | Piperazine, Triazoles, Molecular hybridization, anti-oxidant activity, DPPH. |
| url | https://doi.org/10.5281/zenodo.18770476 |