SYSTEMIC INFLAMMATORY BURDEN AND MULTIORGAN INVOLVEMENT IN ANKYLOSING SPONDYLITIS: CLINICAL PATTERNS, DETERMINANTS, AND THERAPEUTIC IMPLICATIONS
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2026
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| _version_ | 1866901507407872000 |
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| author | Akhmadaliyeva, Gavkhar Karimova, Madinakhon |
| author_facet | Akhmadaliyeva, Gavkhar Karimova, Madinakhon |
| contents | <table> <tbody> <tr> <td> <p><em>Ankylosing spondylitis (AS) is a prototypical form of axial spondyloarthritis characterized by chronic inflammation of the sacroiliac joints and spine, progressive structural damage, and functional impairment. Historically regarded as a disease confined to the axial skeleton, AS is now understood as a systemic inflammatory disorder with diverse clinical expressions.</em></p> <p><em>The pathogenesis of AS involves complex interactions between genetic predisposition, immune dysregulation, and environmental triggers. The strongest genetic association is linked to the HLA-B27 antigen, which plays a critical role in antigen presentation and immune activation. Although HLA-B27 positivity is present in the majority of AS patients, its exact pathogenic contribution remains incompletely elucidated.</em><em> </em></p> </td> </tr> </tbody> </table> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18785943 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | SYSTEMIC INFLAMMATORY BURDEN AND MULTIORGAN INVOLVEMENT IN ANKYLOSING SPONDYLITIS: CLINICAL PATTERNS, DETERMINANTS, AND THERAPEUTIC IMPLICATIONS Akhmadaliyeva, Gavkhar Karimova, Madinakhon <table> <tbody> <tr> <td> <p><em>Ankylosing spondylitis (AS) is a prototypical form of axial spondyloarthritis characterized by chronic inflammation of the sacroiliac joints and spine, progressive structural damage, and functional impairment. Historically regarded as a disease confined to the axial skeleton, AS is now understood as a systemic inflammatory disorder with diverse clinical expressions.</em></p> <p><em>The pathogenesis of AS involves complex interactions between genetic predisposition, immune dysregulation, and environmental triggers. The strongest genetic association is linked to the HLA-B27 antigen, which plays a critical role in antigen presentation and immune activation. Although HLA-B27 positivity is present in the majority of AS patients, its exact pathogenic contribution remains incompletely elucidated.</em><em> </em></p> </td> </tr> </tbody> </table> |
| title | SYSTEMIC INFLAMMATORY BURDEN AND MULTIORGAN INVOLVEMENT IN ANKYLOSING SPONDYLITIS: CLINICAL PATTERNS, DETERMINANTS, AND THERAPEUTIC IMPLICATIONS |
| url | https://doi.org/10.5281/zenodo.18785943 |