EVALUATION OF HYPOGLYCEMIC ACTIVITY OF SWARNAVANGA IN STZ. INDUCED HYPERGLYCEMIC MALE WISTAR RATS-AN EXPERIMENTAL PHARMACOLOGICAL STUDY
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| Format: | Recurso digital |
| Langue: | anglais |
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Zenodo
2026
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| _version_ | 1866901705699885056 |
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| author | Dr. Praveen Kumar G.*1, Dr. Prakash R. Deshpande2, Dr. Veena Nandennavar3 |
| author_facet | Dr. Praveen Kumar G.*1, Dr. Prakash R. Deshpande2, Dr. Veena Nandennavar3 |
| contents | <p><span>Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia and associated systemic complications. Swarnavanga is a kupipakwa kalpa mentioned in Rasa Tarangini indicated in Prameha roga. This study evaluates its hypoglycemic efficacy in Streptozotocin (STZ) induced hyperglycemic male Wistar rats. <strong>Objectives: </strong>To evaluate the hypoglycemic activity of standardized Swarnavanga in STZ-induced hyperglycemic male Wistar rats. </span><strong><span>Methods: </span></strong><span>Swarnavanga was prepared by Kupipakva method using shodhita Parada, Vanga, Gandhaka, and Navasadara following Rasatarangini text.24 male Wistar rats were divided into four groups (n=6 each) Normal control, Diabetic control, Standard(Metformin treated) and test group (Swarnavanga treated). Diabetes was confirmed at 72 hours post-STZ injection. Oral medications were administered for 21 consecutive days. Blood glucose levels were estimated on Days 1, 3, 5, 7, 15, and 21 using the glucose oxidase-peroxidase (GOD-POD) enzymatic method. Statistical analysis was performed using one-way ANOVA followed by Dunnett's t-test (p<0.05). <strong>Results: </strong>Swarnavanga demonstrated significant hypoglycemic activity, representing a 46.2% reduction. Metformin reduced glucose levels representing a 41.1% reduction. No statistically significant difference was observed between Swarnavanga and metformin. <strong>Conclusion: </strong>Swarnavanga exhibits hypoglycemic activityin STZ-induced diabetic rats, validating its traditional claim as Prameha-hara. </span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18799604 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | EVALUATION OF HYPOGLYCEMIC ACTIVITY OF SWARNAVANGA IN STZ. INDUCED HYPERGLYCEMIC MALE WISTAR RATS-AN EXPERIMENTAL PHARMACOLOGICAL STUDY Dr. Praveen Kumar G.*1, Dr. Prakash R. Deshpande2, Dr. Veena Nandennavar3 <p><span>Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia and associated systemic complications. Swarnavanga is a kupipakwa kalpa mentioned in Rasa Tarangini indicated in Prameha roga. This study evaluates its hypoglycemic efficacy in Streptozotocin (STZ) induced hyperglycemic male Wistar rats. <strong>Objectives: </strong>To evaluate the hypoglycemic activity of standardized Swarnavanga in STZ-induced hyperglycemic male Wistar rats. </span><strong><span>Methods: </span></strong><span>Swarnavanga was prepared by Kupipakva method using shodhita Parada, Vanga, Gandhaka, and Navasadara following Rasatarangini text.24 male Wistar rats were divided into four groups (n=6 each) Normal control, Diabetic control, Standard(Metformin treated) and test group (Swarnavanga treated). Diabetes was confirmed at 72 hours post-STZ injection. Oral medications were administered for 21 consecutive days. Blood glucose levels were estimated on Days 1, 3, 5, 7, 15, and 21 using the glucose oxidase-peroxidase (GOD-POD) enzymatic method. Statistical analysis was performed using one-way ANOVA followed by Dunnett's t-test (p<0.05). <strong>Results: </strong>Swarnavanga demonstrated significant hypoglycemic activity, representing a 46.2% reduction. Metformin reduced glucose levels representing a 41.1% reduction. No statistically significant difference was observed between Swarnavanga and metformin. <strong>Conclusion: </strong>Swarnavanga exhibits hypoglycemic activityin STZ-induced diabetic rats, validating its traditional claim as Prameha-hara. </span></p> |
| title | EVALUATION OF HYPOGLYCEMIC ACTIVITY OF SWARNAVANGA IN STZ. INDUCED HYPERGLYCEMIC MALE WISTAR RATS-AN EXPERIMENTAL PHARMACOLOGICAL STUDY |
| url | https://doi.org/10.5281/zenodo.18799604 |