Hepatoprotective Activity of Tectona grandis Root Extract against Paracetamol-induced Hepatotoxicity in Experimental Models
Fuente:
Zenodo
Guardado en:
| Autor principal: | |
|---|---|
| Formato: | Recurso digital |
| Publicado: |
Zenodo
2026
|
| Materias: | |
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866901047264411648 |
|---|---|
| author | Shruti Shukla*, Arvind Kumar Shrivastava, Rishita Shrivastava, Preeti Maurya, Siddharth Kesharwani |
| author_facet | Shruti Shukla*, Arvind Kumar Shrivastava, Rishita Shrivastava, Preeti Maurya, Siddharth Kesharwani |
| contents | <p><span lang="EN-US">The present study investigated the hepatoprotective activity of the ethanolic root extract of Tectona grandis against paracetamol-induced hepatotoxicity in Wistar rats. Roots of T. grandis were extracted using a Soxhlet apparatus and subjected to physicochemical and preliminary phytochemical evaluation. Acute oral toxicity was determined in accordance with OECD guideline 423. Hepatotoxicity was induced by oral administration of paracetamol (2 g/kg). Animals were divided into five groups: normal control, paracetamol control, standard control treated with silymarin (100 mg/kg), and test groups receiving T. grandis root extract treated at doses of 100 and 200 mg/kg. Serum biochemical parameters, including SGPT, SGOT, ALP, total bilirubin, and total protein, were estimated followed Paracetamol exposure resulted in a substantial increase in liver enzymes and bilirubin levels with a reduction in total protein, indicating hepatic injury. Treatment with the extract produced dose-dependent hepatoprotection, with the higher dose showing effects comparable to silymarin. Histopathological findings corroborated biochemical results by demonstrating restoration of normal hepatic architecture. The study confirms the hepatoprotective potential of Tectona grandis root extract.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18810732 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Hepatoprotective Activity of Tectona grandis Root Extract against Paracetamol-induced Hepatotoxicity in Experimental Models Shruti Shukla*, Arvind Kumar Shrivastava, Rishita Shrivastava, Preeti Maurya, Siddharth Kesharwani Tectona grandis; hepatoprotection; paracetamol; liver enzymes; medicinal plants <p><span lang="EN-US">The present study investigated the hepatoprotective activity of the ethanolic root extract of Tectona grandis against paracetamol-induced hepatotoxicity in Wistar rats. Roots of T. grandis were extracted using a Soxhlet apparatus and subjected to physicochemical and preliminary phytochemical evaluation. Acute oral toxicity was determined in accordance with OECD guideline 423. Hepatotoxicity was induced by oral administration of paracetamol (2 g/kg). Animals were divided into five groups: normal control, paracetamol control, standard control treated with silymarin (100 mg/kg), and test groups receiving T. grandis root extract treated at doses of 100 and 200 mg/kg. Serum biochemical parameters, including SGPT, SGOT, ALP, total bilirubin, and total protein, were estimated followed Paracetamol exposure resulted in a substantial increase in liver enzymes and bilirubin levels with a reduction in total protein, indicating hepatic injury. Treatment with the extract produced dose-dependent hepatoprotection, with the higher dose showing effects comparable to silymarin. Histopathological findings corroborated biochemical results by demonstrating restoration of normal hepatic architecture. The study confirms the hepatoprotective potential of Tectona grandis root extract.</span></p> |
| title | Hepatoprotective Activity of Tectona grandis Root Extract against Paracetamol-induced Hepatotoxicity in Experimental Models |
| topic | Tectona grandis; hepatoprotection; paracetamol; liver enzymes; medicinal plants |
| url | https://doi.org/10.5281/zenodo.18810732 |