Longitudinal Boundary Sharpness Coefficient Slopes Predict Time to Alzheimer's Disease Conversion in Mild Cognitive Impairment: A Survival Analysis Using the ADNI Cohort
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| Format: | Recurso digital |
| Language: | English |
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Zenodo
2026
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| _version_ | 1866901201172299776 |
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| author | Cherukuri |
| author_facet | Cherukuri |
| contents | <p>This study predicts when people with mild cognitive impairment (MCI) will convert to Alzheimer's disease using a novel MRI-based biomarker. Instead of looking at brain scans at a single timepoint, the analysis looks at how the gray-white matter interface degrades over time. The Boundary Sharpness Coefficient (BSC) measures how sharp this boundary looks on structural MRI. By computing slopes (annual rates of change) across 4+ longitudinal scans per subject, the study captures disease progression dynamics that static images disregard.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18829786 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Longitudinal Boundary Sharpness Coefficient Slopes Predict Time to Alzheimer's Disease Conversion in Mild Cognitive Impairment: A Survival Analysis Using the ADNI Cohort Cherukuri Neurons Neurons/pathology Neurons/classification <p>This study predicts when people with mild cognitive impairment (MCI) will convert to Alzheimer's disease using a novel MRI-based biomarker. Instead of looking at brain scans at a single timepoint, the analysis looks at how the gray-white matter interface degrades over time. The Boundary Sharpness Coefficient (BSC) measures how sharp this boundary looks on structural MRI. By computing slopes (annual rates of change) across 4+ longitudinal scans per subject, the study captures disease progression dynamics that static images disregard.</p> |
| title | Longitudinal Boundary Sharpness Coefficient Slopes Predict Time to Alzheimer's Disease Conversion in Mild Cognitive Impairment: A Survival Analysis Using the ADNI Cohort |
| topic | Neurons Neurons/pathology Neurons/classification |
| url | https://doi.org/10.5281/zenodo.18829786 |