SafeCREW Analytical Protocol #1 – Advanced analytical procedures for the characterization of sulfonated disinfection byproducts in drinking water
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| Natura: | Recurso digital |
| Lingua: | inglese |
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2026
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| _version_ | 1866902320290201600 |
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| author | Nihemaiti, Maolida |
| author_facet | Nihemaiti, Maolida |
| contents | <p><strong>Introduction</strong></p> <p><span lang="EN-US">Only a small number of DBPs are regulated so far. However, the majority, including the main toxicity drivers in disinfected water, remain unknown. Traditional methods, such as gas chromatography-mass spectrometry (GC-MS) and reversed-phase liquid chromatography-mass spectrometry (RP-LC-MS), are often ineffective for highly polar contaminants, as these compounds are neither sufficiently volatile for GC analysis nor well retained by reversed-phase columns in RP-LC-MS. To address this limitation, the SafeCREW project has developed a novel analytical approach based on supercritical fluid chromatography-mass spectrometry (SFC-MS) enabling the characterisation of previously unknown highly polar sulfonated DBPs in drinking water.<span> </span></span></p> <p><strong><span lang="EN-US"><span>Target audience</span></span></strong></p> <p><span lang="EN-GB">This analytical test protocol targets water utilities and researchers. Utilities can apply it to monitor and manage DBPs in their systems; researchers can use it to design studies on DBP formation mechanism and toxicity.</span></p> <p><strong><span lang="EN-GB">Scope and objective of the analytical protocol</span></strong></p> <p><span lang="EN-GB">This guideline covers advanced analytical procedures for sampling, detecting, identifying, and quantifying highly polar sulfonated DBPs. It focuses on complementary chromatographic techniques, high-resolution and targeted mass spectrometry, and sample-enrichment strategies relevant to drinking water. </span></p> <p><span lang="EN-GB">The objective of this guideline is to provide reliable, sensitive, and practical analytical methods for the characterisation of polar DBPs. It aims to support laboratories and researchers in applying state-of-the-art techniques for comprehensive DBP analysis.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18852970 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | SafeCREW Analytical Protocol #1 – Advanced analytical procedures for the characterization of sulfonated disinfection byproducts in drinking water Nihemaiti, Maolida Analytical method disinfection by-products Drinking water Gas Chromatography-Mass Spectrometry Liquid Chromatography-Mass Spectrometry Chromatography, Supercritical Fluid polar disinfection byproducts sulfonated Water Pollutants disinfection <p><strong>Introduction</strong></p> <p><span lang="EN-US">Only a small number of DBPs are regulated so far. However, the majority, including the main toxicity drivers in disinfected water, remain unknown. Traditional methods, such as gas chromatography-mass spectrometry (GC-MS) and reversed-phase liquid chromatography-mass spectrometry (RP-LC-MS), are often ineffective for highly polar contaminants, as these compounds are neither sufficiently volatile for GC analysis nor well retained by reversed-phase columns in RP-LC-MS. To address this limitation, the SafeCREW project has developed a novel analytical approach based on supercritical fluid chromatography-mass spectrometry (SFC-MS) enabling the characterisation of previously unknown highly polar sulfonated DBPs in drinking water.<span> </span></span></p> <p><strong><span lang="EN-US"><span>Target audience</span></span></strong></p> <p><span lang="EN-GB">This analytical test protocol targets water utilities and researchers. Utilities can apply it to monitor and manage DBPs in their systems; researchers can use it to design studies on DBP formation mechanism and toxicity.</span></p> <p><strong><span lang="EN-GB">Scope and objective of the analytical protocol</span></strong></p> <p><span lang="EN-GB">This guideline covers advanced analytical procedures for sampling, detecting, identifying, and quantifying highly polar sulfonated DBPs. It focuses on complementary chromatographic techniques, high-resolution and targeted mass spectrometry, and sample-enrichment strategies relevant to drinking water. </span></p> <p><span lang="EN-GB">The objective of this guideline is to provide reliable, sensitive, and practical analytical methods for the characterisation of polar DBPs. It aims to support laboratories and researchers in applying state-of-the-art techniques for comprehensive DBP analysis.</span></p> |
| title | SafeCREW Analytical Protocol #1 – Advanced analytical procedures for the characterization of sulfonated disinfection byproducts in drinking water |
| topic | Analytical method disinfection by-products Drinking water Gas Chromatography-Mass Spectrometry Liquid Chromatography-Mass Spectrometry Chromatography, Supercritical Fluid polar disinfection byproducts sulfonated Water Pollutants disinfection |
| url | https://doi.org/10.5281/zenodo.18852970 |