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| Format: | Recurso digital |
| Sprache: | Englisch |
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Zenodo
2026
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| Online-Zugang: | https://doi.org/10.5281/zenodo.18885749 |
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| _version_ | 1866901763193307136 |
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| author | Keshav Bondre*, Sakshi Nagrikar, Akansha Ramteke, Gauri Tatewar, Divyabharati Biradar |
| author_facet | Keshav Bondre*, Sakshi Nagrikar, Akansha Ramteke, Gauri Tatewar, Divyabharati Biradar |
| contents | <p><strong><span>Background:<span> </span></span></strong><span>Alzheimer’s<span> </span>disease<span> </span>(AD)<span> </span>is<span> </span>a<span> </span>progressive<span> </span>neurodegenerative<span> </span>condition<span> </span>primarily<span> </span>marked<span> </span>by<span> </span>a<span> </span>decline<span> </span>in<span> </span>cognitive function and currently has few effective treatment options. Current treatments offer only symptomatic relief and are often associated with adverse effects. In the search for alternative therapies, <em>Vinca minor</em>, a medicinal plant rich in alkaloids and antioxidants, has shown promising neuroprotective potential. <strong>Objective:<span> </span></strong>The<span> </span>aim<span> </span>of<span> </span>the<span> </span>study<span> </span>is<span> </span>to<span> </span>evaluate<span> </span>the<span> </span>neuroprotective<span> </span>effects<span> </span>of<span> </span>Vinca<span> </span>minor<span> </span>leaves<span> </span>extract<span> </span>against<span> </span>chemically<span> </span>induced Alzheimer’s disease in experimental animals. <strong>Methods: </strong>Male<span> </span>Wistar rats<span> </span>were divided into five groups, including normal control, disease control, standard drug, and two test groups receiving <em>Vinca minor </em>extract. A<span> </span>behavioral assessment was conducted using the radial arm maze and the novel object recognition test. Biochemical estimations included acetylcholinesterase (AChE), glutathione (GSH), nitric oxide (NO), and catalase (CAT) levels. Histopathological analysis of the brain tissue was performed to assess neuronal integrity. <strong>Results: </strong>Treatment with <em>Vinca minor </em>significantly improved behavioral performance, enhanced antioxidant enzyme levels, reduced<span> </span>AChE<span> </span>and<span> </span>NO<span> </span>levels,<span> </span>and<span> </span>preserved<span> </span>neuronal<span> </span>architecture<span> </span>in<span> </span>hippocampal<span> </span>regions<span> </span>compared<span> </span>to<span> </span>the<span> </span>disease<span> </span>control<span> </span>group. <strong>Conclusion:<span> </span></strong>The<span> </span>findings<span> </span>suggest<span> </span>that<span> </span><em>Vinca<span> </span>minor<span> </span></em>leaf </span><span>extract<span> </span>exerts<span> </span>cognitive-enhancing<span> </span>and<span> </span>neuroprotective<span> </span>effects,<span> </span>potentially through antioxidant and anticholinesterase mechanisms, supporting its use as a natural therapeutic option in<span> </span>AD management.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_18885749 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | STUDY OF THE EFFECT OF VINCA MINOR LEAVES EXTRACT AGAINST CHEMICALLY INDUCED COGNITIVE IMPAIRMENT IN EXPERIMENTAL ANIMALS Keshav Bondre*, Sakshi Nagrikar, Akansha Ramteke, Gauri Tatewar, Divyabharati Biradar <p><strong><span>Background:<span> </span></span></strong><span>Alzheimer’s<span> </span>disease<span> </span>(AD)<span> </span>is<span> </span>a<span> </span>progressive<span> </span>neurodegenerative<span> </span>condition<span> </span>primarily<span> </span>marked<span> </span>by<span> </span>a<span> </span>decline<span> </span>in<span> </span>cognitive function and currently has few effective treatment options. Current treatments offer only symptomatic relief and are often associated with adverse effects. In the search for alternative therapies, <em>Vinca minor</em>, a medicinal plant rich in alkaloids and antioxidants, has shown promising neuroprotective potential. <strong>Objective:<span> </span></strong>The<span> </span>aim<span> </span>of<span> </span>the<span> </span>study<span> </span>is<span> </span>to<span> </span>evaluate<span> </span>the<span> </span>neuroprotective<span> </span>effects<span> </span>of<span> </span>Vinca<span> </span>minor<span> </span>leaves<span> </span>extract<span> </span>against<span> </span>chemically<span> </span>induced Alzheimer’s disease in experimental animals. <strong>Methods: </strong>Male<span> </span>Wistar rats<span> </span>were divided into five groups, including normal control, disease control, standard drug, and two test groups receiving <em>Vinca minor </em>extract. A<span> </span>behavioral assessment was conducted using the radial arm maze and the novel object recognition test. Biochemical estimations included acetylcholinesterase (AChE), glutathione (GSH), nitric oxide (NO), and catalase (CAT) levels. Histopathological analysis of the brain tissue was performed to assess neuronal integrity. <strong>Results: </strong>Treatment with <em>Vinca minor </em>significantly improved behavioral performance, enhanced antioxidant enzyme levels, reduced<span> </span>AChE<span> </span>and<span> </span>NO<span> </span>levels,<span> </span>and<span> </span>preserved<span> </span>neuronal<span> </span>architecture<span> </span>in<span> </span>hippocampal<span> </span>regions<span> </span>compared<span> </span>to<span> </span>the<span> </span>disease<span> </span>control<span> </span>group. <strong>Conclusion:<span> </span></strong>The<span> </span>findings<span> </span>suggest<span> </span>that<span> </span><em>Vinca<span> </span>minor<span> </span></em>leaf </span><span>extract<span> </span>exerts<span> </span>cognitive-enhancing<span> </span>and<span> </span>neuroprotective<span> </span>effects,<span> </span>potentially through antioxidant and anticholinesterase mechanisms, supporting its use as a natural therapeutic option in<span> </span>AD management.</span></p> |
| title | STUDY OF THE EFFECT OF VINCA MINOR LEAVES EXTRACT AGAINST CHEMICALLY INDUCED COGNITIVE IMPAIRMENT IN EXPERIMENTAL ANIMALS |
| url | https://doi.org/10.5281/zenodo.18885749 |