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Zenodo
2026
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| Online Access: | https://doi.org/10.5281/zenodo.19002459 |
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| _version_ | 1866901231835807744 |
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| author | ueda, takashi |
| author_facet | ueda, takashi |
| contents | <p>This paper proposes a novel biophysical mech-</p> <p>anism for Alzheimer’s disease based on the Non-</p> <p>Equilibrium Unified Theory (NEUT). We hypoth-</p> <p>esize that the accumulation of deuterium (2H) in</p> <p>the brain increases the background complexity field</p> <p>D, shifting the geometric equilibrium radius req of</p> <p>Amyloid-β (Aβ) proteins. Numerical simulations</p> <p>demonstrate that when D exceeds a critical thresh-</p> <p>old (D ≈ 1.5), the repulsive barrier of Aβ monomers</p> <p>is compromised, leading to a ”geometric trap” where</p> <p>neighboring molecules fall into an irreversible attrac-</p> <p>tive phase. This framework identifies the local iso-</p> <p>topic balance as a primary determinant of the indi-</p> <p>vidual variance in neurodegeneration progression.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19002459 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Isotopic Modulation of the Background Field D in Alzheimer's Disease: A Geometric Hypothesis for Amyloid-β Aggregation via Deuterium Accumulation ueda, takashi <p>This paper proposes a novel biophysical mech-</p> <p>anism for Alzheimer’s disease based on the Non-</p> <p>Equilibrium Unified Theory (NEUT). We hypoth-</p> <p>esize that the accumulation of deuterium (2H) in</p> <p>the brain increases the background complexity field</p> <p>D, shifting the geometric equilibrium radius req of</p> <p>Amyloid-β (Aβ) proteins. Numerical simulations</p> <p>demonstrate that when D exceeds a critical thresh-</p> <p>old (D ≈ 1.5), the repulsive barrier of Aβ monomers</p> <p>is compromised, leading to a ”geometric trap” where</p> <p>neighboring molecules fall into an irreversible attrac-</p> <p>tive phase. This framework identifies the local iso-</p> <p>topic balance as a primary determinant of the indi-</p> <p>vidual variance in neurodegeneration progression.</p> |
| title | Isotopic Modulation of the Background Field D in Alzheimer's Disease: A Geometric Hypothesis for Amyloid-β Aggregation via Deuterium Accumulation |
| url | https://doi.org/10.5281/zenodo.19002459 |