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| Format: | Recurso digital |
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| Veröffentlicht: |
Zenodo
2026
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| Online-Zugang: | https://doi.org/10.5281/zenodo.19002459 |
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Inhaltsangabe:
- <p>This paper proposes a novel biophysical mech-</p> <p>anism for Alzheimer’s disease based on the Non-</p> <p>Equilibrium Unified Theory (NEUT). We hypoth-</p> <p>esize that the accumulation of deuterium (2H) in</p> <p>the brain increases the background complexity field</p> <p>D, shifting the geometric equilibrium radius req of</p> <p>Amyloid-β (Aβ) proteins. Numerical simulations</p> <p>demonstrate that when D exceeds a critical thresh-</p> <p>old (D ≈ 1.5), the repulsive barrier of Aβ monomers</p> <p>is compromised, leading to a ”geometric trap” where</p> <p>neighboring molecules fall into an irreversible attrac-</p> <p>tive phase. This framework identifies the local iso-</p> <p>topic balance as a primary determinant of the indi-</p> <p>vidual variance in neurodegeneration progression.</p>