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| Format: | Recurso digital |
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Zenodo
2026
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| Online Access: | https://doi.org/10.5281/zenodo.19016031 |
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Table of Contents:
- <p>Glioblastoma multiforme (GBM) and other high-grade gliomas represent a therapeutic challenge due to the blood-brain barrier (BBB) and a highly immunosuppressive tumor microenvironment (TME). This study explores a multi-targeted phytochemical protocol designed to modulate the inflammatory cascade driving tumorigenesis. Specifically, we investigate the suppression of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway and the subsequent downregulation of pro-inflammatory cytokines, specifically Interleukin-1 beta (IL-1β) and Tumor Necrosis Factor-alpha (TNF-α). By concurrently activating the NRF2 antioxidant pathway, this protocol aims to induce oxidative stress specifically within tumor cells whileprotecting healthy neuronal tissue, offering a novel metabolic deconvolution of brain cancer progression.</p>