| _version_ | 1866901744496148480 |
|---|---|
| author | O'Keeffe, Daniel |
| author_facet | O'Keeffe, Daniel |
| contents | <p><span>We report the identification of a dimensionless ratio—the Integration-Dissipation Ratio (Rᴵᴰ = Sₚᵣₒᵈ / Cₗ)—that behaves as a conserved state variable of macroscopic brain dynamics. In human EEG under propofol sedation (N = 21, OpenNeuro ds005620), Rᴵᴰ is statistically invariant between wakefulness and light sedation with preserved responsiveness (p = 0.48, Bayes Factor = 178.60), and collapses decisively under deep sedation where behavioural responsiveness is abolished (p = 0.0065). The component quantities—thermodynamic entropy production (Sₚᵣₒᵈ) and algorithmic complexity (Cₗ)—decline asymmetrically during this transition (entropy production: −55%; complexity: −16%), quantitatively falsifying the null hypothesis that ratio stability reflects proportional co-decline. Cross-species validation on rat neocortical local field potentials confirms magnitude consistency (4/4 testable criteria pass). Human sleep deprivation EEG confirms the predicted directional elevation of Rᴵᴰ under homeostatic debt (p = 0.033, correct direction in 81% of subjects). All data are publicly available. Full analysis code is provided for independent replication.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19074214 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | A Thermodynamic Invariant of Macroscopic Brain State: The Integration-Dissipation Ratio O'Keeffe, Daniel <p><span>We report the identification of a dimensionless ratio—the Integration-Dissipation Ratio (Rᴵᴰ = Sₚᵣₒᵈ / Cₗ)—that behaves as a conserved state variable of macroscopic brain dynamics. In human EEG under propofol sedation (N = 21, OpenNeuro ds005620), Rᴵᴰ is statistically invariant between wakefulness and light sedation with preserved responsiveness (p = 0.48, Bayes Factor = 178.60), and collapses decisively under deep sedation where behavioural responsiveness is abolished (p = 0.0065). The component quantities—thermodynamic entropy production (Sₚᵣₒᵈ) and algorithmic complexity (Cₗ)—decline asymmetrically during this transition (entropy production: −55%; complexity: −16%), quantitatively falsifying the null hypothesis that ratio stability reflects proportional co-decline. Cross-species validation on rat neocortical local field potentials confirms magnitude consistency (4/4 testable criteria pass). Human sleep deprivation EEG confirms the predicted directional elevation of Rᴵᴰ under homeostatic debt (p = 0.033, correct direction in 81% of subjects). All data are publicly available. Full analysis code is provided for independent replication.</span></p> |
| title | A Thermodynamic Invariant of Macroscopic Brain State: The Integration-Dissipation Ratio |
| url | https://doi.org/10.5281/zenodo.19074214 |