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2026
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| Online Access: | https://doi.org/10.5281/zenodo.19117779 |
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| author | Hake, Vaibhav |
| author_facet | Hake, Vaibhav |
| contents | <p>The concurrent use of herbal supplements and antiretroviral drugs is increasingly prevalent,<br>particularly among individuals living with HIV/HBV, raising important concerns about<br>herb-drug interactions (HDIs). Dandelion root (Taraxacum officinale) is one of the most widely<br>consumed herbal products worldwide, valued for its diuretic, hepatoprotective,<br>anti-inflammatory, and antioxidant properties. Tenofovir, available as tenofovir disoproxil<br>fumarate (TDF) and tenofovir alafenamide (TAF), is a cornerstone nucleotide reverse<br>transcriptase inhibitor used in the management of HIV and hepatitis B virus (HBV) infections.<br>This review critically evaluates the pharmacokinetic and pharmacodynamic mechanisms by<br>which dandelion root may interact with tenofovir, with emphasis on renal transporter-mediated<br>interactions, diuretic effects on drug elimination, P-glycoprotein modulation, and shared<br>nephrotoxic potential. Available evidence from in vitro studies, animal models, and clinical case<br>reports is synthesized to provide clinicians with a comprehensive risk framework. The review<br>concludes with clinical recommendations and proposes areas for future investigation.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19117779 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Drug-Drug Interactions Between Dandelion Root (Taraxacum officinale) and Tenofovir: A Comprehensive Review Hake, Vaibhav <p>The concurrent use of herbal supplements and antiretroviral drugs is increasingly prevalent,<br>particularly among individuals living with HIV/HBV, raising important concerns about<br>herb-drug interactions (HDIs). Dandelion root (Taraxacum officinale) is one of the most widely<br>consumed herbal products worldwide, valued for its diuretic, hepatoprotective,<br>anti-inflammatory, and antioxidant properties. Tenofovir, available as tenofovir disoproxil<br>fumarate (TDF) and tenofovir alafenamide (TAF), is a cornerstone nucleotide reverse<br>transcriptase inhibitor used in the management of HIV and hepatitis B virus (HBV) infections.<br>This review critically evaluates the pharmacokinetic and pharmacodynamic mechanisms by<br>which dandelion root may interact with tenofovir, with emphasis on renal transporter-mediated<br>interactions, diuretic effects on drug elimination, P-glycoprotein modulation, and shared<br>nephrotoxic potential. Available evidence from in vitro studies, animal models, and clinical case<br>reports is synthesized to provide clinicians with a comprehensive risk framework. The review<br>concludes with clinical recommendations and proposes areas for future investigation.</p> |
| title | Drug-Drug Interactions Between Dandelion Root (Taraxacum officinale) and Tenofovir: A Comprehensive Review |
| url | https://doi.org/10.5281/zenodo.19117779 |