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2026
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| Online Access: | https://doi.org/10.5281/zenodo.19149215 |
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| _version_ | 1866901668434542592 |
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| author | Sanni, M Isah, IA Dogara, AB Caleb, M Taingston, CM Mohammed-Durosunlorun, A |
| author_facet | Sanni, M Isah, IA Dogara, AB Caleb, M Taingston, CM Mohammed-Durosunlorun, A |
| contents | <div>ABSTRACT</div> <div>Uterine fibroids (leiomyomas) are benign uterine smooth-muscle tumors with high prevalence among women of African descent. Emerging evidence suggests lipid metabolic dysregulation may play a role in fibroid development and growth. This study aimed to evaluate the lipid profile pattern of women diagnosed with uterine fibroid. We conducted a hospitalbased case-control study from April, 2022 to February, 2023 at a tertiary health care facility, Northwest Nigeria. Women aged 18–50 years with ultrasound-confirmed uterine fibroids (cases; 115) were compared to age and parity‐matched controls without fibroids (115). Fasting serum lipid profile (total cholesterol [TC], triglycerides [TG], high density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C]) were measured colorimetrically. Statistical analyses included t-tests adjusted for age, body mass index and parity. Patients had significantly higher mean HDL-C (p = 0.000), Triglyceride (p = 0.001) with lower TC: HDL-C (p = 0.000) when compared with the controls. Higher insignificant mean Cholesterol in patients was observed compared to the controls (p = 0.050). There was no statistically significant difference in LDL-C between patients and controls (p = 0.296). Our findings in this Nigerian population align with the notion that lipid metabolism may contribute to fibroid pathophysiology.</div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19149215 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Lipid Profile Patterns in Women with Uterine Fibroids: A Case Control Study in Northwestern Nigeria Sanni, M Isah, IA Dogara, AB Caleb, M Taingston, CM Mohammed-Durosunlorun, A Uterine fibroid Dyslipidemia Lipid profile Total Cholesterol LDL HDL Nigeria <div>ABSTRACT</div> <div>Uterine fibroids (leiomyomas) are benign uterine smooth-muscle tumors with high prevalence among women of African descent. Emerging evidence suggests lipid metabolic dysregulation may play a role in fibroid development and growth. This study aimed to evaluate the lipid profile pattern of women diagnosed with uterine fibroid. We conducted a hospitalbased case-control study from April, 2022 to February, 2023 at a tertiary health care facility, Northwest Nigeria. Women aged 18–50 years with ultrasound-confirmed uterine fibroids (cases; 115) were compared to age and parity‐matched controls without fibroids (115). Fasting serum lipid profile (total cholesterol [TC], triglycerides [TG], high density lipoprotein cholesterol [HDL-C], low-density lipoprotein cholesterol [LDL-C]) were measured colorimetrically. Statistical analyses included t-tests adjusted for age, body mass index and parity. Patients had significantly higher mean HDL-C (p = 0.000), Triglyceride (p = 0.001) with lower TC: HDL-C (p = 0.000) when compared with the controls. Higher insignificant mean Cholesterol in patients was observed compared to the controls (p = 0.050). There was no statistically significant difference in LDL-C between patients and controls (p = 0.296). Our findings in this Nigerian population align with the notion that lipid metabolism may contribute to fibroid pathophysiology.</div> |
| title | Lipid Profile Patterns in Women with Uterine Fibroids: A Case Control Study in Northwestern Nigeria |
| topic | Uterine fibroid Dyslipidemia Lipid profile Total Cholesterol LDL HDL Nigeria |
| url | https://doi.org/10.5281/zenodo.19149215 |