ACTIVITY–SATURATION–OSCILLATION LAW v4.4 Frequency-Gated Transport, Saturation-Induced Branching, and Emergent Routing in a Constrained Microtubule Lattice
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2026
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| _version_ | 1866901336893685760 |
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| author | Mitchell , Thomas S. |
| author_facet | Mitchell , Thomas S. |
| contents | <p>This work presents a complete computational model of directed transport on a 13-protofilament microtubule-inspired lattice. The study shows that efficient routing, corridor formation, branching, and regime switching can emerge from five interacting local processes: motor activity, activity-dependent trail deposition and saturation, dynamic release/reattachment, oscillatory modulation, and persistent memory carryover across episodes. Across integrated experiments including global state modulation, saturation × frequency phase maps, memory-release sweeps, multi-episode history, hysteresis/recovery, and full motor transport mode, the engine resolves reproducible transport regimes such as acute focus, exploratory safe, chronic stress, and baseline equilibrium. The results support a falsifiable computational law: in constrained lattices, direction and structure arise from accumulated local history under constraint rather than from central control or explicit global synchronization. This record is intended as an open, citable computational transport framework with biological relevance, not as proof of in vivo microtubule-brain-wave coupling. All code, raw outputs, phase maps, and laboratory results are archived with the record.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19150518 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | ACTIVITY–SATURATION–OSCILLATION LAW v4.4 Frequency-Gated Transport, Saturation-Induced Branching, and Emergent Routing in a Constrained Microtubule Lattice Mitchell , Thomas S. microtubule transport, constrained lattice, intracellular transport, emergent routing, saturation-induced branching, frequency-gated transport, oscillatory modulation, stigmergy, self-organization, motor protein dynamics, kinesin, dynein, trail memory, hysteresis, phase map, computational biology, biophysical modeling, transport regimes, corridor coherence, Mitchellian Framework <p>This work presents a complete computational model of directed transport on a 13-protofilament microtubule-inspired lattice. The study shows that efficient routing, corridor formation, branching, and regime switching can emerge from five interacting local processes: motor activity, activity-dependent trail deposition and saturation, dynamic release/reattachment, oscillatory modulation, and persistent memory carryover across episodes. Across integrated experiments including global state modulation, saturation × frequency phase maps, memory-release sweeps, multi-episode history, hysteresis/recovery, and full motor transport mode, the engine resolves reproducible transport regimes such as acute focus, exploratory safe, chronic stress, and baseline equilibrium. The results support a falsifiable computational law: in constrained lattices, direction and structure arise from accumulated local history under constraint rather than from central control or explicit global synchronization. This record is intended as an open, citable computational transport framework with biological relevance, not as proof of in vivo microtubule-brain-wave coupling. All code, raw outputs, phase maps, and laboratory results are archived with the record.</p> |
| title | ACTIVITY–SATURATION–OSCILLATION LAW v4.4 Frequency-Gated Transport, Saturation-Induced Branching, and Emergent Routing in a Constrained Microtubule Lattice |
| topic | microtubule transport, constrained lattice, intracellular transport, emergent routing, saturation-induced branching, frequency-gated transport, oscillatory modulation, stigmergy, self-organization, motor protein dynamics, kinesin, dynein, trail memory, hysteresis, phase map, computational biology, biophysical modeling, transport regimes, corridor coherence, Mitchellian Framework |
| url | https://doi.org/10.5281/zenodo.19150518 |