| _version_ | 1866901109815115776 |
|---|---|
| author | Navneet, Dr. Nisha Devi*, Jyoti Gupta, Saurabh, Rajdeep Kaur |
| author_facet | Navneet, Dr. Nisha Devi*, Jyoti Gupta, Saurabh, Rajdeep Kaur |
| contents | <p><span>Quercetin, a ubiquitous flavonol present in myriad fruits and vegetables, has constituted a dietary staple across human civilizations for millennia. Extensive investigations have substantiated its pleiotropic bioactivities, encompassing antioxidant, antimicrobial, anti-inflammatory, antiviral, and antineoplastic effects. Its potent radical-scavenging capacity mitigates oxidative stress by neutralizing reactive oxygen species (ROS), thereby safeguarding cellular integrity against peroxidation-induced damage. Quercetin's anti-inflammatory efficacy stems from suppression of pro-inflammatory cytokine synthesis (e.g., TNF-α, IL-6) and enzymatic pathways (e.g., COX-2, NF-κB), positioning it as a viable adjunctive therapeutic for inflammatory pathologies. Neoplastic modulation arises via cell cycle arrest, proliferation inhibition, and apoptosis induction in malignant cells through pathways such as PI3K/Akt and MAPK signaling. Cardiovascular protective effects include hypotensive action, hypocholesterolemic influence, and endothelial homeostasis restoration, underscoring its prophylactic potential against atherosclerotic disorders.This review delineates quercetin's chemical architecture, pharmacodynamic profiles, pharmacokinetic constraints (particularly bioavailability limitations), and extant nano- and liposomal delivery paradigms to augment systemic exposure. Dietary incorporation of quercetin-enriched comestibles or supplementation regimens holds promise for chronic disease prophylaxis and metabolic homeostasis. Emerging translational horizons encompass nutraceutical fortification, pharmaceutical formulations, and functional food matrices to harness its chemopreventive attributes. Nonetheless, prospective research imperatives include mechanistic dissection via omics platforms, bioavailability optimization through novel nanocarriers, and longitudinal safety profiling to endorse clinical translation</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19183657 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Quercetin Review: Chemistry, Pharmacological Activity, Bioavailability Problems, And Nano Innovations Navneet, Dr. Nisha Devi*, Jyoti Gupta, Saurabh, Rajdeep Kaur Flavonoid, Sources of Quercetin, Structure, Bioavailability, Pharmacological Activities <p><span>Quercetin, a ubiquitous flavonol present in myriad fruits and vegetables, has constituted a dietary staple across human civilizations for millennia. Extensive investigations have substantiated its pleiotropic bioactivities, encompassing antioxidant, antimicrobial, anti-inflammatory, antiviral, and antineoplastic effects. Its potent radical-scavenging capacity mitigates oxidative stress by neutralizing reactive oxygen species (ROS), thereby safeguarding cellular integrity against peroxidation-induced damage. Quercetin's anti-inflammatory efficacy stems from suppression of pro-inflammatory cytokine synthesis (e.g., TNF-α, IL-6) and enzymatic pathways (e.g., COX-2, NF-κB), positioning it as a viable adjunctive therapeutic for inflammatory pathologies. Neoplastic modulation arises via cell cycle arrest, proliferation inhibition, and apoptosis induction in malignant cells through pathways such as PI3K/Akt and MAPK signaling. Cardiovascular protective effects include hypotensive action, hypocholesterolemic influence, and endothelial homeostasis restoration, underscoring its prophylactic potential against atherosclerotic disorders.This review delineates quercetin's chemical architecture, pharmacodynamic profiles, pharmacokinetic constraints (particularly bioavailability limitations), and extant nano- and liposomal delivery paradigms to augment systemic exposure. Dietary incorporation of quercetin-enriched comestibles or supplementation regimens holds promise for chronic disease prophylaxis and metabolic homeostasis. Emerging translational horizons encompass nutraceutical fortification, pharmaceutical formulations, and functional food matrices to harness its chemopreventive attributes. Nonetheless, prospective research imperatives include mechanistic dissection via omics platforms, bioavailability optimization through novel nanocarriers, and longitudinal safety profiling to endorse clinical translation</span></p> |
| title | Quercetin Review: Chemistry, Pharmacological Activity, Bioavailability Problems, And Nano Innovations |
| topic | Flavonoid, Sources of Quercetin, Structure, Bioavailability, Pharmacological Activities |
| url | https://doi.org/10.5281/zenodo.19183657 |