Integrative Phytochemical and Cytotoxic Dissection of Desmanthus Virgatus Against Human Lung Adenocarcinoma
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2026
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| author | Balagopalan T. G.1, Vinisha A. P. 2, Nandha Kishore V. S.3, Tharun S.4, Priya K. * |
| author_facet | Balagopalan T. G.1, Vinisha A. P. 2, Nandha Kishore V. S.3, Tharun S.4, Priya K. * |
| contents | <p><span lang="EN-US">The anticancer activity of the ethanolic extract of Desmanthus virgatus was explored against the human lung cancer cell line A549 by phytochemical, insilico, and in vitro methods. The presence of phenolics, flavonoids, tannins, saponins, and alkaloids was confirmed by preliminary phytochemical screening. The GC-MS analysis revealed the presence of major bioactive compounds such as dl-α-tocopherol and ergosta-4,6,22-trien-3-ol. Molecular docking analysis showed strong binding affinity with a cancer-related protein target, which supported the anti proliferative activity. The MTT assay showed dose-dependent cytotoxicity with an IC50 value of 42.79 µg/mL. Morphological alterations in treated cells confirmed apoptosis. The results suggest that <em>D.virgatus </em>is a potential natural source for anticancer compounds.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19217709 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Integrative Phytochemical and Cytotoxic Dissection of Desmanthus Virgatus Against Human Lung Adenocarcinoma Balagopalan T. G.1, Vinisha A. P. 2, Nandha Kishore V. S.3, Tharun S.4, Priya K. * A549 cell line; Anticancer activity; GC-MS analysis; Molecular docking. <p><span lang="EN-US">The anticancer activity of the ethanolic extract of Desmanthus virgatus was explored against the human lung cancer cell line A549 by phytochemical, insilico, and in vitro methods. The presence of phenolics, flavonoids, tannins, saponins, and alkaloids was confirmed by preliminary phytochemical screening. The GC-MS analysis revealed the presence of major bioactive compounds such as dl-α-tocopherol and ergosta-4,6,22-trien-3-ol. Molecular docking analysis showed strong binding affinity with a cancer-related protein target, which supported the anti proliferative activity. The MTT assay showed dose-dependent cytotoxicity with an IC50 value of 42.79 µg/mL. Morphological alterations in treated cells confirmed apoptosis. The results suggest that <em>D.virgatus </em>is a potential natural source for anticancer compounds.</span></p> |
| title | Integrative Phytochemical and Cytotoxic Dissection of Desmanthus Virgatus Against Human Lung Adenocarcinoma |
| topic | A549 cell line; Anticancer activity; GC-MS analysis; Molecular docking. |
| url | https://doi.org/10.5281/zenodo.19217709 |