GLP-1 as Compound Target Operator: Address-Operator Architecture and Geometric Coupling Predictions for Incretin Drug Design
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2026
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| _version_ | 1866901775303311360 |
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| author | Dunn, James E. |
| author_facet | Dunn, James E. |
| contents | Demonstrates that GLP-1(7-36) decomposes into a 10-residue address domain and 20-residue operator domain (1/3 + 2/3 = buffer partition). Structured region = 23 residues exactly. Drug modification sites (DPP-4, acylation, Arg swap) occur at equation constants (1/15, 2/3, 14/15). Helix ratio = 3/2. GLP-1 signals through cAMP→CREB→Z-DNA formation, implementing the chirality switch. Predicts C23 fatty acid chain and dual acylation as geometrically optimal modifications. GCT Research Protocol II. |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19223458 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | GLP-1 as Compound Target Operator: Address-Operator Architecture and Geometric Coupling Predictions for Incretin Drug Design Dunn, James E. GLP-1 incretin semaglutide geometric composition address-operator chirality switch drug design coupling equation Z-DNA Demonstrates that GLP-1(7-36) decomposes into a 10-residue address domain and 20-residue operator domain (1/3 + 2/3 = buffer partition). Structured region = 23 residues exactly. Drug modification sites (DPP-4, acylation, Arg swap) occur at equation constants (1/15, 2/3, 14/15). Helix ratio = 3/2. GLP-1 signals through cAMP→CREB→Z-DNA formation, implementing the chirality switch. Predicts C23 fatty acid chain and dual acylation as geometrically optimal modifications. GCT Research Protocol II. |
| title | GLP-1 as Compound Target Operator: Address-Operator Architecture and Geometric Coupling Predictions for Incretin Drug Design |
| topic | GLP-1 incretin semaglutide geometric composition address-operator chirality switch drug design coupling equation Z-DNA |
| url | https://doi.org/10.5281/zenodo.19223458 |