FORMULATION OF SMART NANOPARTICLE-BASED TOPICAL SYSTEM FOR TARGETED PROTECTION AGAINST DIGITAL BLUE LIGHT SKIN DAMAGE
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2026
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| author | Mr. Utkarsh R. Mandage1*, Ms. Priyanka P. Musale2, Mr. Prasad P. Duphare3, Ms. Megha K. Gulhane4, Ms. Prajakta S. Mahajan5 |
| author_facet | Mr. Utkarsh R. Mandage1*, Ms. Priyanka P. Musale2, Mr. Prasad P. Duphare3, Ms. Megha K. Gulhane4, Ms. Prajakta S. Mahajan5 |
| contents | <p><span lang="EN-IN">The widespread use of digital devices has led to prolonged exposure to blue light, which is increasingly recognized as a contributing factor <span>in</span> skin damage. Blue light penetrates the skin and induces oxidative stress, leading to premature aging, hyperpigmentation, inflammation, and <span>skin barrier impairment</span>. Conventional topical formulations provide limited protection against blue light–induced damage <span>owing</span> to <span>the </span>poor stability and insufficient skin penetration of active compounds. <span>This study aimed</span> to develop a smart nanoparticle-based topical formulation to enhance protection against blue light–induced skin damage. Nanoparticles are prepared using a suitable technique and loaded with <span>antioxidants</span> and <span>photoprotective</span> agents. The prepared nanoparticles <span>were characterized in terms of</span> particle size, polydispersity index, zeta potential, morphology, and encapsulation efficiency. The optimized nanoparticles <span>were</span> incorporated into a topical dosage form, such as a gel or cream, and evaluated for physicochemical properties, stability, spreadability, and in vitro release behavior. The expected results include improved stability of <span>the </span>active ingredients, enhanced skin penetration, and superior protection against blue light–induced oxidative stress compared to conventional formulations. The nanoparticle-based system is anticipated to exhibit significant antioxidant activity and effective <span>blue-light</span> attenuation, thereby reducing cellular damage. In conclusion, the proposed smart nanoparticle-based topical formulation represents a novel, effective, and safe approach for protecting the skin from blue light–induced damage, offering a promising strategy for next-generation dermocosmetic and therapeutic applications.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19281801 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | FORMULATION OF SMART NANOPARTICLE-BASED TOPICAL SYSTEM FOR TARGETED PROTECTION AGAINST DIGITAL BLUE LIGHT SKIN DAMAGE Mr. Utkarsh R. Mandage1*, Ms. Priyanka P. Musale2, Mr. Prasad P. Duphare3, Ms. Megha K. Gulhane4, Ms. Prajakta S. Mahajan5 <p><span lang="EN-IN">The widespread use of digital devices has led to prolonged exposure to blue light, which is increasingly recognized as a contributing factor <span>in</span> skin damage. Blue light penetrates the skin and induces oxidative stress, leading to premature aging, hyperpigmentation, inflammation, and <span>skin barrier impairment</span>. Conventional topical formulations provide limited protection against blue light–induced damage <span>owing</span> to <span>the </span>poor stability and insufficient skin penetration of active compounds. <span>This study aimed</span> to develop a smart nanoparticle-based topical formulation to enhance protection against blue light–induced skin damage. Nanoparticles are prepared using a suitable technique and loaded with <span>antioxidants</span> and <span>photoprotective</span> agents. The prepared nanoparticles <span>were characterized in terms of</span> particle size, polydispersity index, zeta potential, morphology, and encapsulation efficiency. The optimized nanoparticles <span>were</span> incorporated into a topical dosage form, such as a gel or cream, and evaluated for physicochemical properties, stability, spreadability, and in vitro release behavior. The expected results include improved stability of <span>the </span>active ingredients, enhanced skin penetration, and superior protection against blue light–induced oxidative stress compared to conventional formulations. The nanoparticle-based system is anticipated to exhibit significant antioxidant activity and effective <span>blue-light</span> attenuation, thereby reducing cellular damage. In conclusion, the proposed smart nanoparticle-based topical formulation represents a novel, effective, and safe approach for protecting the skin from blue light–induced damage, offering a promising strategy for next-generation dermocosmetic and therapeutic applications.</span></p> |
| title | FORMULATION OF SMART NANOPARTICLE-BASED TOPICAL SYSTEM FOR TARGETED PROTECTION AGAINST DIGITAL BLUE LIGHT SKIN DAMAGE |
| url | https://doi.org/10.5281/zenodo.19281801 |