Unexpected Splenic Uptake of 99mTc-HMDP on Bone Scintigraphy in an Adult Patient with Sickle Cell Disease: A Diagnostic Pitfall and Pathophysiological Correlation
Fuente:
Zenodo
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Recurso digital |
| Published: |
Zenodo
2026
|
| Online Access: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1866901081114542080 |
|---|---|
| author | A. Muhoza E. Kpekpeou G. Rossito M. Chaoui A. El Boukhrissi N. Ismaili Alaoui N. Andrian |
| author_facet | A. Muhoza E. Kpekpeou G. Rossito M. Chaoui A. El Boukhrissi N. Ismaili Alaoui N. Andrian |
| contents | <h1><em><span>Abstract</span></em></h1> <p><em><span>Bone scintigraphy using 99mTc‑hydroxymethylene diphosphonate (HMDP) is routinely employed to assess bone metabolism, usually without visualization of extraosseous soft tissues apart from the urinary tract. Splenic uptake of this tracer is unusual, particularly in adult patients with sickle cell disease, because functional or anatomical asplenia is commonly observed as a consequence of repeated splenic infarctions. </span></em></p> <p><em><span>We report the case of a 57‑year‑old woman with long‑standing sickle cell disease, a history of multiple blood transfusions, and a spleen not visualized on recent ultrasound. During bone scintigraphy performed for right hip pain, faint but definite splenic uptake of 99mTc‑HMDP was observed, together with nonspecific visceral opacifications and bone changes consistent with sickle‑related infarctions. The absence of recent contrast‑enhanced cross‑sectional imaging limited the direct assessment of calcifications. This splenic uptake was interpreted as secondary to dystrophic fibro‑calcific remodeling after infarction, promoted by chronic iron overload and chelation therapy. Splenic visualization of 99mTc‑HMDP in an adult patient with sickle cell disease must be interpreted with caution and should not be equated with residual splenic function. Clinical correlation and multimodality imaging are essential. This finding represents a diagnostic pitfall and should not be misinterpreted as residual splenic function. Careful clinical correlation and multimodal imaging assessment are essential.</span></em></p> <p><em><span> </span></em></p> <p><strong><em><span>Keywords:</span></em></strong><em><span> Sickle cell disease, Splenic uptake, Bone scintigraphy, 99mTc‑HMDP. </span></em></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19355837 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Unexpected Splenic Uptake of 99mTc-HMDP on Bone Scintigraphy in an Adult Patient with Sickle Cell Disease: A Diagnostic Pitfall and Pathophysiological Correlation A. Muhoza E. Kpekpeou G. Rossito M. Chaoui A. El Boukhrissi N. Ismaili Alaoui N. Andrian <h1><em><span>Abstract</span></em></h1> <p><em><span>Bone scintigraphy using 99mTc‑hydroxymethylene diphosphonate (HMDP) is routinely employed to assess bone metabolism, usually without visualization of extraosseous soft tissues apart from the urinary tract. Splenic uptake of this tracer is unusual, particularly in adult patients with sickle cell disease, because functional or anatomical asplenia is commonly observed as a consequence of repeated splenic infarctions. </span></em></p> <p><em><span>We report the case of a 57‑year‑old woman with long‑standing sickle cell disease, a history of multiple blood transfusions, and a spleen not visualized on recent ultrasound. During bone scintigraphy performed for right hip pain, faint but definite splenic uptake of 99mTc‑HMDP was observed, together with nonspecific visceral opacifications and bone changes consistent with sickle‑related infarctions. The absence of recent contrast‑enhanced cross‑sectional imaging limited the direct assessment of calcifications. This splenic uptake was interpreted as secondary to dystrophic fibro‑calcific remodeling after infarction, promoted by chronic iron overload and chelation therapy. Splenic visualization of 99mTc‑HMDP in an adult patient with sickle cell disease must be interpreted with caution and should not be equated with residual splenic function. Clinical correlation and multimodality imaging are essential. This finding represents a diagnostic pitfall and should not be misinterpreted as residual splenic function. Careful clinical correlation and multimodal imaging assessment are essential.</span></em></p> <p><em><span> </span></em></p> <p><strong><em><span>Keywords:</span></em></strong><em><span> Sickle cell disease, Splenic uptake, Bone scintigraphy, 99mTc‑HMDP. </span></em></p> |
| title | Unexpected Splenic Uptake of 99mTc-HMDP on Bone Scintigraphy in an Adult Patient with Sickle Cell Disease: A Diagnostic Pitfall and Pathophysiological Correlation |
| url | https://doi.org/10.5281/zenodo.19355837 |