PHARMACOLOGICAL INSIGHTS INTO ANTIOXIDANT AND NOOTROPIC POTENTIAL OF ALANGIUM SALVIFOLIUM IN TRAUMATIC BRAIN INJURY: A PRECLINICAL REVIEW
Fuente:
Zenodo
Guardado en:
| Autores principales: | , |
|---|---|
| Formato: | Recurso digital |
| Publicado: |
Zenodo
2026
|
| Acceso en línea: | |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| _version_ | 1866901126374227968 |
|---|---|
| author | Shahin Banu Mr. Rakesh Sharma |
| author_facet | Shahin Banu Mr. Rakesh Sharma |
| contents | <p>Abstract- Traumatic brain injury (TBI)<br>plays a critical role in understanding the<br>therapeutic potential of Alangium<br>salvifolium in traumatic brain injury.<br>The involvement of oxidative stress,<br>mitochondrial dysfunction,<br>excitotoxicity, and inflammatory<br>cascades contributes significantly to<br>neuronal degeneration and cognitive<br>impairment. Numerous preclinical<br>investigations have demonstrated that<br>phytochemical-rich extracts can<br>modulate these pathways effectively.<br>The presence of flavonoids, alkaloids,<br>and phenolic compounds contributes to<br>free radical scavenging, enhancement of<br>endogenous antioxidant enzymes, and<br>stabilization of neuronal membranes.<br>Furthermore, experimental animal<br>models have shown improvements in<br>spatial memory, learning behavior, and<br>neurochemical balance following<br>administration of plant extracts. These<br>findings strongly support the hypothesis<br>that natural compounds can serve as<br>multi-targeted therapeutic agents in<br>neurodegenerative conditions such as<br>traumatic brain injury. The involvement<br>of oxidative stress, mitochondrial<br>dysfunction, excitotoxicity, and<br>inflammatory cascades contributes<br>significantly to neuronal degeneration<br>and cognitive impairment. Numerous<br>preclinical investigations have<br>demonstrated that phytochemical-rich<br>extracts can modulate these pathways<br>effectively. The presence of flavonoids,<br>alkaloids, and phenolic compounds<br>contributes to free radical scavenging,<br>enhancement of endogenous antioxidant<br>enzymes, and stabilization of neuronal<br>membranes. Furthermore, experimental<br>animal models have shown<br>improvements in spatial memory,<br>learning behavior, and neurochemical<br>balance following administration of<br>plant extracts. These findings strongly<br>support the hypothesis that natural<br>compounds can serve as multi-targeted<br>therapeutic agents in neurodegenerative<br>conditions such as traumatic brain<br>injury. The involvement of oxidative<br>stress, mitochondrial dysfunction,<br>excitotoxicity, and inflammatory<br>cascades contributes significantly to<br>neuronal degeneration and cognitive<br>impairment. Numerous preclinical<br>investigations have demonstrated that<br>phytochemical-rich extracts can<br>modulate these pathways effectively.<br>The presence of flavonoids, alkaloids,<br>and phenolic compounds contributes to<br>free radical scavenging, enhancement of<br>endogenous antioxidant enzymes, and<br>stabilization of neuronal membranes.<br>Furthermore, experimental animal<br>models have shown improvements in<br>spatial memory, learning behavior, and<br>neurochemical balance following<br>administration of plant extracts. These<br>findings strongly support the hypothesis<br>that natural compounds can serve as<br>multi-targeted therapeutic agents in<br>neurodegenerative conditions such as<br>traumatic brain injury.</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19394509 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | PHARMACOLOGICAL INSIGHTS INTO ANTIOXIDANT AND NOOTROPIC POTENTIAL OF ALANGIUM SALVIFOLIUM IN TRAUMATIC BRAIN INJURY: A PRECLINICAL REVIEW Shahin Banu Mr. Rakesh Sharma <p>Abstract- Traumatic brain injury (TBI)<br>plays a critical role in understanding the<br>therapeutic potential of Alangium<br>salvifolium in traumatic brain injury.<br>The involvement of oxidative stress,<br>mitochondrial dysfunction,<br>excitotoxicity, and inflammatory<br>cascades contributes significantly to<br>neuronal degeneration and cognitive<br>impairment. Numerous preclinical<br>investigations have demonstrated that<br>phytochemical-rich extracts can<br>modulate these pathways effectively.<br>The presence of flavonoids, alkaloids,<br>and phenolic compounds contributes to<br>free radical scavenging, enhancement of<br>endogenous antioxidant enzymes, and<br>stabilization of neuronal membranes.<br>Furthermore, experimental animal<br>models have shown improvements in<br>spatial memory, learning behavior, and<br>neurochemical balance following<br>administration of plant extracts. These<br>findings strongly support the hypothesis<br>that natural compounds can serve as<br>multi-targeted therapeutic agents in<br>neurodegenerative conditions such as<br>traumatic brain injury. The involvement<br>of oxidative stress, mitochondrial<br>dysfunction, excitotoxicity, and<br>inflammatory cascades contributes<br>significantly to neuronal degeneration<br>and cognitive impairment. Numerous<br>preclinical investigations have<br>demonstrated that phytochemical-rich<br>extracts can modulate these pathways<br>effectively. The presence of flavonoids,<br>alkaloids, and phenolic compounds<br>contributes to free radical scavenging,<br>enhancement of endogenous antioxidant<br>enzymes, and stabilization of neuronal<br>membranes. Furthermore, experimental<br>animal models have shown<br>improvements in spatial memory,<br>learning behavior, and neurochemical<br>balance following administration of<br>plant extracts. These findings strongly<br>support the hypothesis that natural<br>compounds can serve as multi-targeted<br>therapeutic agents in neurodegenerative<br>conditions such as traumatic brain<br>injury. The involvement of oxidative<br>stress, mitochondrial dysfunction,<br>excitotoxicity, and inflammatory<br>cascades contributes significantly to<br>neuronal degeneration and cognitive<br>impairment. Numerous preclinical<br>investigations have demonstrated that<br>phytochemical-rich extracts can<br>modulate these pathways effectively.<br>The presence of flavonoids, alkaloids,<br>and phenolic compounds contributes to<br>free radical scavenging, enhancement of<br>endogenous antioxidant enzymes, and<br>stabilization of neuronal membranes.<br>Furthermore, experimental animal<br>models have shown improvements in<br>spatial memory, learning behavior, and<br>neurochemical balance following<br>administration of plant extracts. These<br>findings strongly support the hypothesis<br>that natural compounds can serve as<br>multi-targeted therapeutic agents in<br>neurodegenerative conditions such as<br>traumatic brain injury.</p> |
| title | PHARMACOLOGICAL INSIGHTS INTO ANTIOXIDANT AND NOOTROPIC POTENTIAL OF ALANGIUM SALVIFOLIUM IN TRAUMATIC BRAIN INJURY: A PRECLINICAL REVIEW |
| url | https://doi.org/10.5281/zenodo.19394509 |