ROLE OF SERUM INTERLEUKIN-6 AS AN INFLAMMATORY MARKER IN ISCHEMIC HEART DISEASE BEFORE AND TWO HOURS AFTER CORONARY ARTERY STENTING
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2026
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| _version_ | 1866901590132129792 |
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| author | *1Mohammed Mutar Nazzal, 2Amal Al-Marayati, 3Abdul-Kareem Jassim Abood |
| author_facet | *1Mohammed Mutar Nazzal, 2Amal Al-Marayati, 3Abdul-Kareem Jassim Abood |
| contents | <p><strong><span>Background:</span></strong><span> Inflammation plays a central role in the pathogenesis of ischemic heart disease (IHD), and interleukin-6 (IL-6) has emerged as a key biomarker associated with atherosclerosis progression and plaque instability. Its role in patients undergoing percutaneous coronary intervention (PCI) remains clinically significant. <strong>Objective:</strong> This study aimed to evaluate serum IL-6 levels in patients with IHD before and two hours after coronary artery stenting, and to assess its association with clinical presentation, risk factors, and angiographic severity. <strong>Methods:</strong> A descriptive cross-sectional study was conducted on 70 patients with IHD (including STEMI, NSTEMI/unstable angina, and stable angina) undergoing coronary angiography and bare-metal stent implantation, along with 20 healthy controls. Clinical evaluation, risk factor assessment, and angiographic classification were performed. Serum IL-6 levels were measured before catheterization and two hours post-stenting using ELISA techniques. Statistical analysis was carried out using SPSS, with significance set at p<0.05. <strong>Results:</strong> Serum IL-6 levels were significantly higher in IHD patients compared to healthy controls and increased further after stenting. Elevated IL-6 levels were associated with higher-risk clinical presentations, particularly in STEMI patients. Significant correlations were observed between IL-6 levels and age, gender, diabetes mellitus, and severity of coronary lesions. IL-6 levels were consistently higher two hours post-stenting across all patient groups. <strong>Conclusion:</strong> IL-6 is a valuable inflammatory biomarker in IHD, correlating with disease severity and clinical risk. Its elevation following stenting highlights its role in post-procedural inflammatory response, suggesting potential utility in risk stratification and monitoring outcomes in patients undergoing PCI.</span></p> <p><span> </span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19436224 |
| institution | Zenodo |
| language | eng |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | ROLE OF SERUM INTERLEUKIN-6 AS AN INFLAMMATORY MARKER IN ISCHEMIC HEART DISEASE BEFORE AND TWO HOURS AFTER CORONARY ARTERY STENTING *1Mohammed Mutar Nazzal, 2Amal Al-Marayati, 3Abdul-Kareem Jassim Abood <p><strong><span>Background:</span></strong><span> Inflammation plays a central role in the pathogenesis of ischemic heart disease (IHD), and interleukin-6 (IL-6) has emerged as a key biomarker associated with atherosclerosis progression and plaque instability. Its role in patients undergoing percutaneous coronary intervention (PCI) remains clinically significant. <strong>Objective:</strong> This study aimed to evaluate serum IL-6 levels in patients with IHD before and two hours after coronary artery stenting, and to assess its association with clinical presentation, risk factors, and angiographic severity. <strong>Methods:</strong> A descriptive cross-sectional study was conducted on 70 patients with IHD (including STEMI, NSTEMI/unstable angina, and stable angina) undergoing coronary angiography and bare-metal stent implantation, along with 20 healthy controls. Clinical evaluation, risk factor assessment, and angiographic classification were performed. Serum IL-6 levels were measured before catheterization and two hours post-stenting using ELISA techniques. Statistical analysis was carried out using SPSS, with significance set at p<0.05. <strong>Results:</strong> Serum IL-6 levels were significantly higher in IHD patients compared to healthy controls and increased further after stenting. Elevated IL-6 levels were associated with higher-risk clinical presentations, particularly in STEMI patients. Significant correlations were observed between IL-6 levels and age, gender, diabetes mellitus, and severity of coronary lesions. IL-6 levels were consistently higher two hours post-stenting across all patient groups. <strong>Conclusion:</strong> IL-6 is a valuable inflammatory biomarker in IHD, correlating with disease severity and clinical risk. Its elevation following stenting highlights its role in post-procedural inflammatory response, suggesting potential utility in risk stratification and monitoring outcomes in patients undergoing PCI.</span></p> <p><span> </span></p> |
| title | ROLE OF SERUM INTERLEUKIN-6 AS AN INFLAMMATORY MARKER IN ISCHEMIC HEART DISEASE BEFORE AND TWO HOURS AFTER CORONARY ARTERY STENTING |
| url | https://doi.org/10.5281/zenodo.19436224 |