BIOCHEMICAL MONITORING AND MANAGEMENT OF MINERAL METABOLISM DISORDERS IN CHRONIC KIDNEY DISEASE PATIENTS ON HEMODIALYSIS
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| Formato: | Recurso digital |
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2026
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| _version_ | 1866902032652173312 |
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| author | Makhmonov L.S., Rizaev J.A., Gadaev A.G. Worldy Knovledge Publishing Centre |
| author_facet | Makhmonov L.S., Rizaev J.A., Gadaev A.G. Worldy Knovledge Publishing Centre |
| contents | <p><strong> </strong>This study investigates the correlational relationships among five key biochemical parameters — serum phosphorus, calcium, vitamin D, parathyroid hormone (PTH), and fibroblast growth factor-23 (FGF-23) — in 30 patients at the initiation of hemodialysis therapy. Using Pearson correlation analysis, statistically significant interdependencies were identified among all five parameters (p < 0.001). A near-perfect positive correlation between phosphorus and FGF-23 (r = 0.994), a strong negative correlation between phosphorus and vitamin D (r = −0.856), and a strong positive correlation between calcium and vitamin D (r = 0.955) were observed. These findings demonstrate profound disruption of the phosphorus–calcium–vitamin D–PTH–FGF-23 axis at dialysis initiation and highlight the need for comprehensive biochemical monitoring in chronic kidney disease management [1–5].</p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19510223 |
| institution | Zenodo |
| language | |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | BIOCHEMICAL MONITORING AND MANAGEMENT OF MINERAL METABOLISM DISORDERS IN CHRONIC KIDNEY DISEASE PATIENTS ON HEMODIALYSIS Makhmonov L.S., Rizaev J.A., Gadaev A.G. Worldy Knovledge Publishing Centre <p><strong> </strong>This study investigates the correlational relationships among five key biochemical parameters — serum phosphorus, calcium, vitamin D, parathyroid hormone (PTH), and fibroblast growth factor-23 (FGF-23) — in 30 patients at the initiation of hemodialysis therapy. Using Pearson correlation analysis, statistically significant interdependencies were identified among all five parameters (p < 0.001). A near-perfect positive correlation between phosphorus and FGF-23 (r = 0.994), a strong negative correlation between phosphorus and vitamin D (r = −0.856), and a strong positive correlation between calcium and vitamin D (r = 0.955) were observed. These findings demonstrate profound disruption of the phosphorus–calcium–vitamin D–PTH–FGF-23 axis at dialysis initiation and highlight the need for comprehensive biochemical monitoring in chronic kidney disease management [1–5].</p> |
| title | BIOCHEMICAL MONITORING AND MANAGEMENT OF MINERAL METABOLISM DISORDERS IN CHRONIC KIDNEY DISEASE PATIENTS ON HEMODIALYSIS |
| url | https://doi.org/10.5281/zenodo.19510223 |