PLACE PREFERENCE INDUCED BY ELECTRICAL STIMULATION OF PARABRACHIAL COMPLEX: BEHAVIOURAL EFFECTS OF NALOXONE.
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| Natura: | Recurso digital |
| Lingua: | inglese |
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Zenodo
2019
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| _version_ | 1866901885010575360 |
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| author | Garcia, Raquel Hurtado, M. M. Simon, Maria J. Puerto, Amadeo |
| author_facet | Garcia, Raquel Hurtado, M. M. Simon, Maria J. Puerto, Amadeo |
| contents | <p class="MsoNormal"><span>Previous studies have shown that electrical stimulation of the external lateral </span><span>parabrachial nucleus (PBle) has rewarding effects</span><span> in different learning tasks, and that they can be blocked by the administration of naloxone. However, for the correct execution of these tasks, animals should manifest intact motor skills.</span></p> <p class="MsoNormal"><span><span> </span>In this experiment, place preferences were induced by intracranial electrical stimulation of the PBle in a rectangular maze with three compartments. Subsequently, after the administration of 4 mg/kg of naloxone, a similar procedure was carried out in a new maze in which horizontal crossings and vertical rearings of the animals were recorded.</span></p> <p class="MsoNormal"><span>Results have shown that the administration of naloxone only blocked the acquisition of preferences in a new maze. In addition, analysis of the animal behaviour revealed that this inhibitory effect of the opiate antagonist cannot be interpreted in terms of motor deficits, since statistically significant differences in horizontal or vertical activity of the rodents were not found after the administration of naloxone. </span></p> <p class="MsoNormal"><span>These results are discussed in terms of a </span><span>possible involvement of the </span><span>external lateral </span><span>parabrachial nucleus </span><span>in different brain rewarding systems.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19520872 |
| institution | Zenodo |
| language | eng |
| publishDate | 2019 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | PLACE PREFERENCE INDUCED BY ELECTRICAL STIMULATION OF PARABRACHIAL COMPLEX: BEHAVIOURAL EFFECTS OF NALOXONE. Garcia, Raquel Hurtado, M. M. Simon, Maria J. Puerto, Amadeo <p class="MsoNormal"><span>Previous studies have shown that electrical stimulation of the external lateral </span><span>parabrachial nucleus (PBle) has rewarding effects</span><span> in different learning tasks, and that they can be blocked by the administration of naloxone. However, for the correct execution of these tasks, animals should manifest intact motor skills.</span></p> <p class="MsoNormal"><span><span> </span>In this experiment, place preferences were induced by intracranial electrical stimulation of the PBle in a rectangular maze with three compartments. Subsequently, after the administration of 4 mg/kg of naloxone, a similar procedure was carried out in a new maze in which horizontal crossings and vertical rearings of the animals were recorded.</span></p> <p class="MsoNormal"><span>Results have shown that the administration of naloxone only blocked the acquisition of preferences in a new maze. In addition, analysis of the animal behaviour revealed that this inhibitory effect of the opiate antagonist cannot be interpreted in terms of motor deficits, since statistically significant differences in horizontal or vertical activity of the rodents were not found after the administration of naloxone. </span></p> <p class="MsoNormal"><span>These results are discussed in terms of a </span><span>possible involvement of the </span><span>external lateral </span><span>parabrachial nucleus </span><span>in different brain rewarding systems.</span></p> |
| title | PLACE PREFERENCE INDUCED BY ELECTRICAL STIMULATION OF PARABRACHIAL COMPLEX: BEHAVIOURAL EFFECTS OF NALOXONE. |
| url | https://doi.org/10.5281/zenodo.19520872 |