Formulation and Evaluation of Picrorhiza Kurroa Based Polyherbal Syrup for Liver Cirrhosis
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2026
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| author | Minakshi Khairnar*1, Dimple Shinde2, Harshada Mahajan2, Piyusha Patil2, Mansi Gaikwad2, Asmita Kothawade2 |
| author_facet | Minakshi Khairnar*1, Dimple Shinde2, Harshada Mahajan2, Piyusha Patil2, Mansi Gaikwad2, Asmita Kothawade2 |
| contents | <p class="MsoNormal"><span>Liver cirrhosis is a chronic and progressive disorder characterized by fibrosis and impaired hepatic function, primarily caused by oxidative stress and inflammation. Conventional therapies are often associated with limitations such as adverse effects and high cost, thereby necessitating the development of safer and effective herbal alternatives. The present study aimed to formulate and evaluate a polyherbal syrup based on Picrorhiza kurroa for its physicochemical properties, microbiological quality, antioxidant potential, and stability, with the objective of identifying an optimized formulation for hepatoprotective application. Three batches (Batch I, Batch II, and Batch III) of polyherbal syrup were formulated using Picrorhiza kurroa, Andrographis paniculata, and Glycyrrhiza glabra, along with piperine as a bioavailability enhancer. The formulations were evaluated for organoleptic properties, pH, viscosity, specific gravity, total solid content, microbial load (TAMC and TYMC) and short-term as well as accelerated stability studies for up to three months. All formulations exhibited acceptable physicochemical characteristics and complied with pharmacopeial limits for microbial load. Batch II demonstrated optimal organoleptic properties, balanced pH (5.8–5.9), appropriate viscosity, and ideal total solid content. Microbiological evaluation revealed the lowest TAMC (90 CFU/mL) and TYMC (30 CFU/mL) in Batch II. Stability studies confirmed that Batch II remained physically and microbiologically stable over three months with minimal variation in evaluated parameters. The results indicate that the developed polyherbal syrup is stable, safe and suitable for oral administration. Batch II was identified as the optimized formulation due to its superior physicochemical properties, microbial stability and overall performance</span><span>.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19583378 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
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| spellingShingle | Formulation and Evaluation of Picrorhiza Kurroa Based Polyherbal Syrup for Liver Cirrhosis Minakshi Khairnar*1, Dimple Shinde2, Harshada Mahajan2, Piyusha Patil2, Mansi Gaikwad2, Asmita Kothawade2 Picrorhiza Kurroa, Andrographis Paniculate, Glycyrrhiza Glabra, Hepatoprotective <p class="MsoNormal"><span>Liver cirrhosis is a chronic and progressive disorder characterized by fibrosis and impaired hepatic function, primarily caused by oxidative stress and inflammation. Conventional therapies are often associated with limitations such as adverse effects and high cost, thereby necessitating the development of safer and effective herbal alternatives. The present study aimed to formulate and evaluate a polyherbal syrup based on Picrorhiza kurroa for its physicochemical properties, microbiological quality, antioxidant potential, and stability, with the objective of identifying an optimized formulation for hepatoprotective application. Three batches (Batch I, Batch II, and Batch III) of polyherbal syrup were formulated using Picrorhiza kurroa, Andrographis paniculata, and Glycyrrhiza glabra, along with piperine as a bioavailability enhancer. The formulations were evaluated for organoleptic properties, pH, viscosity, specific gravity, total solid content, microbial load (TAMC and TYMC) and short-term as well as accelerated stability studies for up to three months. All formulations exhibited acceptable physicochemical characteristics and complied with pharmacopeial limits for microbial load. Batch II demonstrated optimal organoleptic properties, balanced pH (5.8–5.9), appropriate viscosity, and ideal total solid content. Microbiological evaluation revealed the lowest TAMC (90 CFU/mL) and TYMC (30 CFU/mL) in Batch II. Stability studies confirmed that Batch II remained physically and microbiologically stable over three months with minimal variation in evaluated parameters. The results indicate that the developed polyherbal syrup is stable, safe and suitable for oral administration. Batch II was identified as the optimized formulation due to its superior physicochemical properties, microbial stability and overall performance</span><span>.</span></p> |
| title | Formulation and Evaluation of Picrorhiza Kurroa Based Polyherbal Syrup for Liver Cirrhosis |
| topic | Picrorhiza Kurroa, Andrographis Paniculate, Glycyrrhiza Glabra, Hepatoprotective |
| url | https://doi.org/10.5281/zenodo.19583378 |