THE ROLE OF BIOMARKERS OF INFLAMMATION AND ENDOTOXIN-BINDING SYSTEMS IN THE STRATIFICATION OF CARDIOVASCULAR RISK IN PATIENTS WITH TYPE 1 DIABETES MELLITUS
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| Formato: | Recurso digital |
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2026
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| _version_ | 1866901307346911232 |
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| author | Useinova R. Kh. Beloglazov V. A. Yatskov I. A. Ageeva E. S. Repinskaya I. N. |
| author_facet | Useinova R. Kh. Beloglazov V. A. Yatskov I. A. Ageeva E. S. Repinskaya I. N. |
| contents | <p class="MsoNormal"><span>The problem of early detection of structural and functional predictors of cardiac remodeling in patients with type 1 diabetes mellitus (DM1) is characterized by growing relevance. Due to the expansion of understanding of diabetic cardiomyopathy, one of the key roles in the etiopathogenesis of which is played by chronic inflammation and endotoxinemia, the study of the role of biomarkers reflecting these pathogenetic links is of particular interest. The aim is to evaluate the prognostic value of lipopolysaccharide-binding protein (LBP), highly sensitive C-reactive protein (hs-CRP) and high-density lipoproteins (HDL) in detecting myocardial remodeling in patients with DM1. Material and methods. The study included 78 patients of the endocrinology department «N.A. Semashko RCH» with a diagnosis of DM1. The median age was 35 (23.0-42.35) full years. The patients underwent general clinical studies, as well as an enzyme immunoassay (ELISA) study of blood plasma to determine the level of LBP (mcg/ ml) and hs-CRP (mg/l). The instrumental study included transthoracic echocardiography with an assessment of the left ventricular mass and left ventricular mass index, the thickness of the interventricular septum and the posterior wall of the left ventricle. The prognostic value of the studied markers was assessed using ROC analysis.<span> </span>Statistical processing was performed using the IBM SPSS Statistics 27 program. Results. ROC analysis showed high diagnostic efficacy of LBP for detecting LV hypertrophy: the area under the curve (AUC) was 0.778 (95% CI: 0.649-0.907), p=0.001. The threshold value of LBP was defined as >8.02 mg/l (sensitivity 88.9%, specificity 66.7%). For hs-CRP, the threshold value was >1.62 mg/l (AUC=0.767), for HDL – <1.34 mmol/l (AUC=0.736), p=0.001. Conclusion. It has been established that LBP, hs-CRP and HDL are significant predictors of myocardial remodeling in DM1. </span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19633581 |
| institution | Zenodo |
| language | rus |
| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | THE ROLE OF BIOMARKERS OF INFLAMMATION AND ENDOTOXIN-BINDING SYSTEMS IN THE STRATIFICATION OF CARDIOVASCULAR RISK IN PATIENTS WITH TYPE 1 DIABETES MELLITUS Useinova R. Kh. Beloglazov V. A. Yatskov I. A. Ageeva E. S. Repinskaya I. N. diabetes mellitus lipopolysaccharide-binding protein highly sensitive C-reactive protein left ventricular remodeling left ventricular myocardial mass index <p class="MsoNormal"><span>The problem of early detection of structural and functional predictors of cardiac remodeling in patients with type 1 diabetes mellitus (DM1) is characterized by growing relevance. Due to the expansion of understanding of diabetic cardiomyopathy, one of the key roles in the etiopathogenesis of which is played by chronic inflammation and endotoxinemia, the study of the role of biomarkers reflecting these pathogenetic links is of particular interest. The aim is to evaluate the prognostic value of lipopolysaccharide-binding protein (LBP), highly sensitive C-reactive protein (hs-CRP) and high-density lipoproteins (HDL) in detecting myocardial remodeling in patients with DM1. Material and methods. The study included 78 patients of the endocrinology department «N.A. Semashko RCH» with a diagnosis of DM1. The median age was 35 (23.0-42.35) full years. The patients underwent general clinical studies, as well as an enzyme immunoassay (ELISA) study of blood plasma to determine the level of LBP (mcg/ ml) and hs-CRP (mg/l). The instrumental study included transthoracic echocardiography with an assessment of the left ventricular mass and left ventricular mass index, the thickness of the interventricular septum and the posterior wall of the left ventricle. The prognostic value of the studied markers was assessed using ROC analysis.<span> </span>Statistical processing was performed using the IBM SPSS Statistics 27 program. Results. ROC analysis showed high diagnostic efficacy of LBP for detecting LV hypertrophy: the area under the curve (AUC) was 0.778 (95% CI: 0.649-0.907), p=0.001. The threshold value of LBP was defined as >8.02 mg/l (sensitivity 88.9%, specificity 66.7%). For hs-CRP, the threshold value was >1.62 mg/l (AUC=0.767), for HDL – <1.34 mmol/l (AUC=0.736), p=0.001. Conclusion. It has been established that LBP, hs-CRP and HDL are significant predictors of myocardial remodeling in DM1. </span></p> |
| title | THE ROLE OF BIOMARKERS OF INFLAMMATION AND ENDOTOXIN-BINDING SYSTEMS IN THE STRATIFICATION OF CARDIOVASCULAR RISK IN PATIENTS WITH TYPE 1 DIABETES MELLITUS |
| topic | diabetes mellitus lipopolysaccharide-binding protein highly sensitive C-reactive protein left ventricular remodeling left ventricular myocardial mass index |
| url | https://doi.org/10.5281/zenodo.19633581 |