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| Format: | Recurso digital |
| Sprache: | Englisch |
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Zenodo
2022
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| Online-Zugang: | https://doi.org/10.5281/zenodo.19650447 |
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| _version_ | 1866901710403796992 |
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| author | MA. Chrischelle F., Bullecer |
| author_facet | MA. Chrischelle F., Bullecer |
| contents | <p>This study assessed the diuretic potential of methanolic extract of<em> Hydrocotyle vulgaris </em>in albino mice after oral administration. Methanolic extract of <em>H. vulgaris</em> (40 and 20mg/kg) and the reference drug, Furosemide (20mg/kg) were administered intraperitoneally using the modified Lipschitz method. All animals were pretreated with saline before commencing the experiment. Their urine output and electrolyte changes were quantitated at several intervals of time after the dose of 5 hours and after 24 hours. The urine output increased significantly in Furosemide and in both 40 and 20mg/kg extracts (p<0.05). Methanolic extract of <em>H. vulgaris</em> increased the urine volume and electrolyte balance in a dose-dependent manner and qualitatively similar to that of Furosemide. These findings collectively indicate that the extract exhibited significant diuretic activity, providing evidence, at least in part, for its traditional use as a diuretic.</p> <p>published by the <a href="https://innspub.net/journal-of-biodiversity-and-environmental-sciences/"><strong>Journal of Biodiversity and Environmental Sciences | JBES</strong></a></p> <div class="journal__description"> <div class="journal__description-text"> </div> </div> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19650447 |
| institution | Zenodo |
| language | eng |
| publishDate | 2022 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | Assessment of the diuretic activity of Hydrocotyle vulgaris methanolic extract in Albino Mice MA. Chrischelle F., Bullecer Diuretic potential Methanolic extract Hydrocotyle vulgaris Furosemide Urine output <p>This study assessed the diuretic potential of methanolic extract of<em> Hydrocotyle vulgaris </em>in albino mice after oral administration. Methanolic extract of <em>H. vulgaris</em> (40 and 20mg/kg) and the reference drug, Furosemide (20mg/kg) were administered intraperitoneally using the modified Lipschitz method. All animals were pretreated with saline before commencing the experiment. Their urine output and electrolyte changes were quantitated at several intervals of time after the dose of 5 hours and after 24 hours. The urine output increased significantly in Furosemide and in both 40 and 20mg/kg extracts (p<0.05). Methanolic extract of <em>H. vulgaris</em> increased the urine volume and electrolyte balance in a dose-dependent manner and qualitatively similar to that of Furosemide. These findings collectively indicate that the extract exhibited significant diuretic activity, providing evidence, at least in part, for its traditional use as a diuretic.</p> <p>published by the <a href="https://innspub.net/journal-of-biodiversity-and-environmental-sciences/"><strong>Journal of Biodiversity and Environmental Sciences | JBES</strong></a></p> <div class="journal__description"> <div class="journal__description-text"> </div> </div> |
| title | Assessment of the diuretic activity of Hydrocotyle vulgaris methanolic extract in Albino Mice |
| topic | Diuretic potential Methanolic extract Hydrocotyle vulgaris Furosemide Urine output |
| url | https://doi.org/10.5281/zenodo.19650447 |