CALCIUM-PHOSPHATE HOMEOSTASIS DISTURBANCES IN PEDIATRIC PATIENTS WITH CHRONIC GASTROINTESTINAL DISORDERS: CLINICAL MANIFESTATIONS AND PATHOGENETIC MECHANISMS
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2026
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| author | Khodjayeva, Iroda |
| author_facet | Khodjayeva, Iroda |
| contents | <p class="MsoNormal"><span>Disturbances of calcium-phosphate metabolism represent a clinically significant and frequently underrecognized complication of chronic gastrointestinal (GI) diseases in children; however, the pathogenetic mechanisms underlying these disturbances across different nosological entities remain incompletely characterized. The present prospective comparative study examined clinical manifestations and laboratory markers of calcium-phosphate homeostasis in 72 children with chronic GI diseases admitted to the National Children's Medical Center (NCMC, Tashkent, Uzbekistan). Patients were stratified into three groups according to their primary diagnosis: chronic gastroduodenitis (CGD), inflammatory bowel disease (IBD), and malabsorption syndrome (MAS). The severity of calcium-phosphate homeostasis disturbances was found to increase progressively in the sequence CGD → IBD → MAS and was determined both by the degree of mucosal inflammatory involvement and by the depth of nutrient absorption impairment. Vitamin D deficiency was documented in 17.9%, 54.2%, and 80.0% of patients in the CGD, IBD, and MAS groups, respectively. Secondary hyperparathyroidism was identified in 7.1%, 41.7%, and 65.0% of patients, while reduced bone mineral density (BMD) was detected in 10.7%, 37.5%, and 70.0% of cases. The strongest predictors of BMD reduction were serum 25(OH)D (r = 0.72), parathyroid hormone (r = −0.68), and ionized calcium (r = 0.64). The identified clinicopathogenetic patterns provide a scientific basis for developing differentiated approaches to the diagnosis and correction of mineral metabolism disturbances in this patient population.</span></p> |
| format | Recurso digital |
| id | zenodo_https___doi_org_10_5281_zenodo_19660890 |
| institution | Zenodo |
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| publishDate | 2026 |
| publisher | Zenodo |
| record_format | zenodo |
| spellingShingle | CALCIUM-PHOSPHATE HOMEOSTASIS DISTURBANCES IN PEDIATRIC PATIENTS WITH CHRONIC GASTROINTESTINAL DISORDERS: CLINICAL MANIFESTATIONS AND PATHOGENETIC MECHANISMS Khodjayeva, Iroda <p class="MsoNormal"><span>Disturbances of calcium-phosphate metabolism represent a clinically significant and frequently underrecognized complication of chronic gastrointestinal (GI) diseases in children; however, the pathogenetic mechanisms underlying these disturbances across different nosological entities remain incompletely characterized. The present prospective comparative study examined clinical manifestations and laboratory markers of calcium-phosphate homeostasis in 72 children with chronic GI diseases admitted to the National Children's Medical Center (NCMC, Tashkent, Uzbekistan). Patients were stratified into three groups according to their primary diagnosis: chronic gastroduodenitis (CGD), inflammatory bowel disease (IBD), and malabsorption syndrome (MAS). The severity of calcium-phosphate homeostasis disturbances was found to increase progressively in the sequence CGD → IBD → MAS and was determined both by the degree of mucosal inflammatory involvement and by the depth of nutrient absorption impairment. Vitamin D deficiency was documented in 17.9%, 54.2%, and 80.0% of patients in the CGD, IBD, and MAS groups, respectively. Secondary hyperparathyroidism was identified in 7.1%, 41.7%, and 65.0% of patients, while reduced bone mineral density (BMD) was detected in 10.7%, 37.5%, and 70.0% of cases. The strongest predictors of BMD reduction were serum 25(OH)D (r = 0.72), parathyroid hormone (r = −0.68), and ionized calcium (r = 0.64). The identified clinicopathogenetic patterns provide a scientific basis for developing differentiated approaches to the diagnosis and correction of mineral metabolism disturbances in this patient population.</span></p> |
| title | CALCIUM-PHOSPHATE HOMEOSTASIS DISTURBANCES IN PEDIATRIC PATIENTS WITH CHRONIC GASTROINTESTINAL DISORDERS: CLINICAL MANIFESTATIONS AND PATHOGENETIC MECHANISMS |
| url | https://doi.org/10.5281/zenodo.19660890 |